Glucagon

Question 1

Glucagon: Generic Name

Answer 1

Glucagon

Question 2

Glucagon: Trade Name

Answer 2

GlucaGen

Question 3

Glucagon: Class

Answer 3

Anti-hypoglycemic, antidote

Question 4

Glucagon: Action

Answer 4

Raises blood glucose level. Induces liver glycogen breakdown, releasing glucose from the liver. Blood glucose is raised within 10m. Has a half-life of 8 to 18m. Unknown mechanism for use in Beta-Blocker OD’s

Question 5

Glucagon: Indications

Answer 5

Rx of severe hypoglycemia without IV access, Helpful in reversing adverse beta-blockade of beta-adrenergic blocking agents and calcium channel blockers

Question 6

Glucagon: Contraindications

Answer 6

Hypersensitivity, hyperglycemia

Question 7

Glucagon: S. E.

Answer 7

Hyperglycemia (excessive dosage), nausea and vomiting hypersensitivity reactions (anaphylaxis, dyspnea, hypotension, rash), increased blood pressure, and pulse; this maybe greater in pts taking beta-blockers.

Question 8

Glucagon: Supplied

Answer 8

One vial containing 1 mg. (1 IU) powder and one vial containing 1/ml of sterile water to be reconstituted.

Question 9

Glucagon: Adult dose

Answer 9

1 mg. IM, for symptomatic diabetic pt whose IV access unsuccessful. For Beta-blocker or Calcium channel blocker OD give 3-10 mg IV slowly

Question 10

Glucagon: Pedi dose

Answer 10

Hypoglycemia 0.03-0.1 mg/kg IM, SQ slow push, may be repeated in 20m. For Beta Blocker or Calcium Channel Blocker OD: 0.05-0.15mg/kg IV or IO over 3-5 minutes

Question 11

Glucagon: Considerations

Answer 11

Give with caution to pts that have low levels of releasable glucose (e.g., adrenal insufficiency, chronic hypoglycemia, and prolonged fasting). Potentiates oral anticoagulants. Depletes glycogen stores especially in children and adolescents