Etomidate

Question 1

Etomidate: Generic Name

Answer 1

Etomidate

Question 2

Etomidate: Trade Name

Answer 2

Amidate

Question 3

Etomidate: Class

Answer 3

General Anesthetic. Is a hypnotic with no analgesic activity

Question 4

Etomidate: Action

Answer 4

Produces general anesthesia by augmenting the inhibitory tone of GABA on the CNS. Specific site of action is believed to be the reticular activating system. ETOMIDATE HAS NO ANALGESIC EFFECTS

Question 5

Etomidate: Pharmacokinetics

Answer 5

The onset is 1-2 minutes with a duration of 2-5 minutes. The half life is approximately 75 minutes. Elimination is primarily by the liver by converting to inactive metabolites and excreted in the urine.

Question 6

Etomidate: Pharmacodynamics

Answer 6

CNS: Produces unconsciousness in approximately 30-60 seconds with recovery in 3-5 minutes due to rapid redistribution.

Cardiovascular: Minimal changes in HR, BP, CO. Preferred agent in hemodynamically compromised pt. Can get tachycardia and HTN with tracheal intubation.

Respiratory: Dose dependent respiratory depression and apnea.

Question 7

Etomidate: S. E.

Answer 7

Myoclonus may occur after administration particularly with stimulation. Pain with injection due to being dissolved in propylene glycol. N/V may occur more frequently after its use. Adrenal suppression is noted but usually only with prolonged use as in an infusion. Frequently see eye movements with injection.

Question 8

Etomidate: Supplied

Answer 8

Pre-filled syringes and multi-dose vial. Usually 2 mg/ml.

Question 9

Etomidate: Adult Dose

Answer 9

20mg

Question 10

Etomidate: Pedi Dose

Answer 10

0.3mg/kg