Final Histo - Circulatory System Flashcards
What does the heart wall contain
cardiac muscle fibrous skeleton intrinsic conduction system coronary vasculature serous membrane endothelial cells and underlying connective tissue
What makes up the fibrous skeleton of the heart
four fibrous rings surrounding valve orifices
two fibrous trigones connecting rings
membranous portion of inter ventricular and interatrial septa
What tissue makes up the fibrous rings surrounding the valve orifices
dense irregular connective tissue
This is the outer layer; visceral layer of serous pericardium
epicardium
This is the middle layer; composed primarily of cardiac muscle, also contains the fibrous skeleton of the heart
myocardium
This is the inner layer of the heart wall
endocardium
What are the three components of the endocardium
endothelial cells
underlying dense connective tissue and smooth muscle
connective tissue
This is the inner layer of the endocardium
endothelial cells
This is the middle layer of the endocardium
underlying layer of dense connective tissue and smooth muscle cells
This is the deep layer of the endocardium
connective tissue containing the intrinsic conduction system
This is the “sac” surrounding the beginning and end of the heart and great vessels
pericardium
What type of tissue are the valves covered in
connective tissue with overlying endothelium
This is loose connective tissue covered in endothelium on atrial or blood vessels side of vavlue
spongiosa
What is the function of the spongiosa
shick absorber; it contains loosely arranged collagen and elastic fibers infiltrated with proteoglycans
This is the core of a valve; contains fibrous extensions from the dense irregular connective tissue of skeletal rings
fibrosa
This is the dense connective tissue with layers of elastic fibers covered in endothelium; adjacent to ventricular side of the valve
ventricularis
What is special about the cardiac muscle of the heart
it is able to depolarize and contract without impulses from the nervous system, due to the intrinsic cardiac conduction system
What type of cell is the intrinsic cardiac conduction system composed of
the 1% non contractile cardiac cells called cardiac conducting cells or auto rhythmic cells
How are the auto rhythmic cells organized
into nodes and highly specialized conducting fibers/tracts called Purkinje fibers
What are auto rhythmic cells responsible for
the initiation and distribution of impulses throughout the heart
What is the rate of the intrinsic cardiac muscle contraction controlled by
it is set by the pacemaker cell and is altered by the sympathetic and parasympathetic nervous system as well as hormones
These modified cardiac muscle cells are found in the SA and AV nodes and are smaller than surrounding atrial contractile cardiac cells; contain fewer myofibrils and lack intercalated discs
nodal cardiac cells
These modified cardiac muscle cells are found in the AV bundle, bundle branches, and sub endothelial branches and are larger than the surrounding ventricular contractile cells
purkinje fibers
Purkinje cells contains what in their periphery and what is different about their nuclei
contain myofibrils at periphery
nuclei are round and larger than nuclei of regular cardiac fibers
What is specifically found in the Purkinje fibers
large amounts of glycogen
What are the three layers of blood vessels
tunica interna or tunica intima
tunica media
tunica externa or tunica adventitia
What are the three parts of the tunica interna
endothelium
basal lamina
subendothelial layer
This is the internal elastic membrane of arteries and some arterioles; part of the tunica interna
subendothelial layer
This contains rings of smooth muscle cells responsible for vasoconstriction and vasodilation; can also contain sheets or lamellae or laminae of elastin
tunica media
This is found in larger vessels and contains the vasa vasorum (vessels of the vessel) and nervi vascularis
tunica externa or tunica adventitia
In cross section, which vessel looks more open and which one looks more collapsed
arteries = open veins = collapsed
In arteries, which layers is the thickest
tunica media
In veins, which layer is the thickest
tunica externa
These are the largest diameter arteries (greater than 10mm)
elastic or conducting arteries (large)
What do the large artery wall contain
large amount of elastic fibers which allow for it to expand and recoil propelling blood onward and as a pressure reserve
These are the medium sized arteries (2-10mm)
muscular or distributing arteries (medium)
What do the walls of the medium sized arteries contain
large amounts of smooth muscle important for regulating blood flow, those in a circular orientation are responsible for vasoconstriction and vasodilation
These are arteries 0.1mm to 2mm in diameter with as many as eight layers of smooth muscle
small arteries
These are arteries with the smallest diameter 10µm to 100µm; only one or two layers of smooth muscle
arterioles
This layer of the large arteries has an inconspicuous internal elastic membrane
tunica intima
This layer of the large arteries is the thickest and contains multiple layers of smooth muscle separated by elastic lamellae
tunica media
This layer of the large arteries is thin and may contain a vasa vasorum and nervi vascularis
tunica adventitia
This layer of the medium arteries is thinner than they of the large arteries and has a prominent internal elastic layer
tunica interna
This layer of the medium arteries is the thickest layer consisting of almost entirely of smooth muscle cells separated by elastic material; has a prominent eternal elastic membrane
tunica media
This layer of the medium arteries is relatively thick and many contain a vasa vasorum or nervi vascularis
tunica adventitia
This layer of the small arteries typically has an internal elastic membrane
tunica intima
This layer of the small arteries contains as many as eight layers of smooth muscle
tunica media
This layer of the small arteries is thin and ill defined
tunica adventitia
This layer of the arterioles may or may not have an internal elastic membrane
tunica intima
This layer of the arterioles has only one or two layers of smooth muscle
tunica media
This layer of the arterioles is thin and ill defined
tunica adventitia
These are the smallest diameter of blood vessels; 4µm-10µm
capillaries
What makes up the wall of capillaries
endothelial cells and its basal lamina
What is the function of capillaries
allow the exchange of material between the blood and body tissues
What are the three types of capillaries
continuous
fenestrated
discontinuous (sinusoidal)
Where are continuous capillaries found
in muscle, lung, and CNS
What types of cell/vessels are found in continuous capillaries
uninterrupted endothelial cell lining with tight or occluding junction
pinocutotic vessels
may see pericytes
Where are fenestrated capillaries found
endocrine glands and at sites of fluid and metabolite absorption
What types of cells/vessels are found in fenestrated capillaries
pinocytotic vessels
have oval proes cnned fenestrations
Where are discontinuous capillaries found
liver, speen, and bone marrow
larger in diameter and more irregularly shaped
What is the name of the flow of blood from an arteriole through a capillary network to a post capillary venule
microcirculation
What comprises the microcirculatory bed or microvascular bed
arteriole
capillary network
postcapillary venule
What are the two types of vessels in the capillary network
true capillaries
arteriovenous (AV) anastomoses or shunts
The more the precapillary sphincters relax and the smooth muscle of the AV shunt contracts, what happens
more blood will pass through the true capillaries in the capillary beds
The more the pre capillary sphincters contract and the smooth muscle AV shunts relax, what happens
the more blood will pass through the arteriovenous anastomoses and bypass the true capillaries
What are the four types of veins
venule
small veins
medium veins
large veins
These are the smallest diameter veins (10µm-100µm) they receive blood from the capillaries
venule
This type of venule has an endothelial cell with basal lamina and pericytes; no tunica media or adventitia
postcapillary venule
This type of venule posses a tunica media with one or two layers of smooth muscle and a thin tunica adventitia; typically no pericytes
muscular venule
This type of vein range from 0.1mm-1mm in diameter and receive blood from muscular venule
small veins
This type of vein ranges from 1mm-10mm in diameter and all three layers are present
medium veins
This type of vein is large than 10mm in diameter and all three layers are present
large veins
This layer of medium veins contains endothelium and its basal lamina, a thin sub endothelial layer with an occasional smooth muscle cell, and in some cases, a thin internal elastic membrane
tuncia intima
This layer of the medium veins is thinner than the associated artery, several layers of smooth muscles (mostly circular) with interspersed collagen and elastic fibers
tunica media
This layer of the medium veins is thicker than the other ; made of collagen and networks of elastic fibers
tunica adventitia
This layer of the large veins is composed of endothelium and its basal lamina, along with a thin sub endothelial layer with some smooth muscle cells
tunica intima
This layer of the large veins is relatively thin; circularly arranged smooth muscle cells
tunica media
This layer of the large veins is thicker than the others; collagen and elastic fibers with the occasional smooth muscle cell
tunica adventitia
Most veins in the limbs have what
valves; thin folds of tunica intima which prevents back flow of blood