Exam 2: Borrelia, Brachyspira, and Treponema Flashcards
gram (-), loosely coiled spirochete which commonly cause arthropod borne infections
Borrelia
T/F Boorrelia are rapid growing
F. slow
T/F. Borrelia are microaerophilic
T
T/F Borrelia have circular chromosomes
F Linear
Which spp. of Borrelia cause lyme dz?
B. burgdorferi
Which spp. of borrelia causes avian septicemic borreliosis
B. anserina
Which spp. of Borrelia causes relapsing fever borrelia and how is it spread?
B. recurrentis, spread by human body louse
which type of tick transmits lyme dz
ixodes scapularis
Which spp can get lyme dz
humans, dogs, horses, cattle, shep
after a tick ingests Lyme infected blood from an animal, spirochetes up regulate expression of _______, which is essential for virulence in mamals
Outer surface protein
What is the main virulence factor of Borrelia
LPS
What is the importance of LPS in borrelia spp.
Ability to hide out in L forms, spherplast, cyctic dormant form in the host
where does borrilia burgdorferi LPS transform from Osp C to Osp A
In the midgut of tics
WHere does B. brgdorferi LPS transform from Osp A to Osp C?
in the salivary gland of ticks
What Osp is transferred from ticks to mammals?
Osp C
T/F in the case of canine Lyme disease an antibody titer does not predict illness
T
List some methods of Dx of Lyme Dz
- direct detection in host tissue
- Culture and isolation
- Serology (SNAP), western blot, ELISA
Tx for lyme dz
doxycycline or minocycline
What are the two types of lyme vaccine?
- OSPA
2. OSPC which kills tick when feeds
Which spp. of Brachyspira causes swine dysentery in growing pigs?
B. hyodysenteriae
WHich spp of Brachyspira causees Intestinal spirochetosis in animals and humans?
B. pilosicoli
Which spps. of brachyspira have a controversial role in disease?
B. intermedia
B. mudochii
B. innocens
B. canis
Anaerobic spirochete agent of swine dysentery
B. hyodysenteriae
Where is B. hyodysenteriae an obligate pathogen?
swine colon (and mice)
