Exam 1: Gram Positive Bacillus Flashcards
Large square - end gram + rods in chains
Bacillus
T/F Bacilli can be aerobes or facultative anaerobes
T
Are Bacillus Catalase + or -?
+
Are Bacillus oxidase + or -?
-
Are Bacillus motile or non-motile
Motile except B. anthracis
Where is bacillus found?
soil
T/F. Most Bacillus species are non-pathogenic environmental organisms
T
What is the most important species of Bacillus?
Bacillus anthracis
The most durable type of cell found in nature
Endospores
T/F. Endospores are produced extracellularly
F. produced intracellularly and excreted extra.
What are the 2 major virulence factors of Bacillus anthracis?
- capsule
2. tripartie anthrax toxin
What is the Bacillus anthracis capsule made up of and what is its function?
polymers of D-glutamic acid, anti-phagocytic
What are the 3 proteins encoded on pXO1 for anthrax toxin?
- Protective antigen (PA)
- Edema factor (EF)
- Lethal Factor (LF)
Anthrax toxin protein thatis responsible for necrosis and hemorrhage
LF
Anthrax toxin protien responsible for edema
EF
Anthrax toxin protein responsible for translocation into cell
Protective antigen
List the predisposing factors that inc. exposure of animals to anthrax
- History of anthrax deaths
- Soil conditions (pH>6, Rich in Ca and N, inc. moisture)
- Warm temp
- Flooding and evaporation cycles
- Drought conditions
What are the 3 species of bacillus that are important for vet med?
- Bacillus anthracis
- Bacillus cereus
- Bacillus licheniformis
What species of animals are affected by Bacillus anthracis
Cattle, sheep, pigs, horses
Subacute anthrax in horses with localized edema. Septicemia with colic and enteritis
Bacillus anthracis
Which species acquire per acute septicemia when infected with anthrax
cattle
WHich species acquire acute septicemia when infected with anthrax
Horse
List some c/s of per acute septicemia in ruminants infected with Bacillus anthrax
- Bleeding from orfices
- dark unclotted blood
- incomplete rigor mortis
- splenomegaly
T/F. Anthrax is an obligatory reportable disease.
T
What are the 4 routes of infection of anthrax in humans?
- cutaneous
- intestinal
- pulmonary
- injection