Enzymes Flashcards

1
Q

function of an enzyme

A

speed up reactions

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2
Q

an enzyme only has

A

one reaction

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3
Q

breakdown to generate energy

A

catabolic

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4
Q

build up requiring energy

A

anabolic

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5
Q

what attaches to the binding site

A

reactant (substrate)

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6
Q

cofactor aka

A

coenzyme

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7
Q

what makes the cofactor holoenzyme

A

enzyme + cofactor

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8
Q

what regulates rate of enzyme synthesis at the dna level

A

steroids

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9
Q

what is a zymogen

A

protein that becomes active enzyme when parts are removed

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10
Q

what regulates zymogen activation

A

proteolytic cleavage

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11
Q

rate limiting step of krebs

A

isocitrate dehydrogenase

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12
Q

rate limiting step of hmp shunt

A

glucose-6-phosphate dehydrogenase

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13
Q

rate limiting step of fatty acid synth

A

acetyl coa carboxylase

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14
Q

rate limiting step of beta oxidation

A

carnitine acyltransferase 1

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15
Q

rate limiting step of urea cycle

A

carbamoyl phosphate synthetase 1

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16
Q

rate limiting step of glycolysis

A

phosphofructokinase

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17
Q

rate limiting step of trypsin

A

hydrolase

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18
Q

what controls mechanisms for cellular metabolism

A

phosphorylation and dephosphorylation

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19
Q

what is an area on the enzyme where a compound may bind and change the rate of activity called

A

allosteric site

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20
Q

what do substrates do

A

stimulate reaction

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21
Q

what do products do

A

inhibit reaction

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22
Q

reaction of velocity is proportional to

A

enzyme concentration

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23
Q

what are saturated and reach max velocity

A

all binding sites

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24
Q

what is the concentration of substrate at which an enzyme yields 1/2 vmax called

A

michaelis-menten constant

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25
example of zymogen activation
pepsinogen to pepsin
26
what transfers a phosphate , atp and mg++
kinase
27
what moves hydrogen
oxidoreductase
28
example of catabolic oxidoreductase
nad+, fad
29
example of anabolic oxidoreductase
nadp | glycerol 3-p dehydrogenase
30
what does nad do
breaks molecules
31
what does nadh do
build molecules
32
tyrosine forms
epinephrine
33
epinephrine stimulates
production of energy
34
epinephrine inhibits
storage of energy
35
insulin comes from
islets of langerhans
36
what makes insulin
beta cells
37
insulin is secreted by
pancreas (tail)
38
insulin stimulates
energy storage
39
insulin inhibits
hormone sensitive liapse
40
what lowers blood sugar
insulin
41
what raises blood sugar
glucagon
42
what do the alpha cells of the pancreas secrete
glucagon
43
what does glucagon stimulate
glycogenolysis
44
what does glucagon and epinephrine stimulate
hormone sensitive lipase
45
glucagon function
release glucose into blood
46
derivative of steroid hormones is called
cholesterol
47
what does cholesterol do
synthesis of particular enzymes and proteins
48
where is cholesterol produced
adrenal cortex
49
what promotes gluconeogenesis
glucocorticoids
50
what do glucocorticoids do
increase break down, increase beta oxidation and ketogenesis
51
cortisol (hydroxycortisone and cortisone) are examples of
glucocorticoids
52
what are important in regulating electrolyte balance, enhance retention of na and excretion of k, ammonia and protons
mineralocorticoids
53
aldosterone is a
mineralocorticoid
54
gonadocorticoids aka
sex hormone
55
what steroid is responsible for secondary sexual characteristics
gonadocorticoids
56
what is the gonadocorticoid in the male
androgens
57
what is the gonadocorticoid in the female
estrogen and progestins
58
what releases arachidonic acid from phospholipids
phospholipase a2
59
which thyroid hormone inhibits protein synthesis and have negative nitrogen balance
t3
60
what increases the t3 and t4 hormone
graves disease
61
what does pth do in for the kidneys
calcitriol synthesis
62
where is leptin produced
in adipose
63
what is stimulated during glucose production
glucagon and epi
64
what is inhibited during glucose production
insulin
65
what is stimulated during glycogen production
insulin
66
what is inhibited during glycogen production
glucagon and epi
67
what is stimulated during glucose splitting
insulin
68
what is inhibited during glucose splitting
glucagon and epi
69
what is stimulated during glycogen splitting
glucagon and epi
70
what is inhibited during glycogen splitting
insulin
71
what is stimulated during fat production
insulin
72
what is inhibited during fat production
glucagon and epi
73
what is stimulated during fat splitting
glucagon and epi
74
what is inhibited during fat splitting
insulin