Endocrine Review 2 Flashcards

1
Q

What endocrine disease causes bilaterally symmetrical alopecia?

A

Hyperadrenocorticism (Cushing’s)

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2
Q

What endocrine disease produces a pendulous abdomen?

A

Hyperadrenocorticism (Cushing’s)

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3
Q

Calcinosis cutis is a consequence of which endocrine disease?

A

Hyperadrenocorticism (Cushing’s)

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4
Q

What is the typical reason that a Cushingoid dog presents to the vet?

A

“Being old” and urinating in inappropriate places

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5
Q

Excessive panting can be a clinical sign of which endocrine disease?

A

Hyperadrenocorticism (Cushing’s)

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6
Q

What type of hyperadrenocorticism (Cushing’s) is most common?

A

PDH (80-85% of cases)

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7
Q

Pituitary dependent hyperadrenocorticism (Cushing’s) is caused by what?

A

ACTH-secreting tumor

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8
Q

What is the ratio of adrenal carcinoma: adrenal adenomas that cause hyperadrenocorticism (Cushing’s)?

A

50/50

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9
Q

How common are bilateral adrenal tumors?

A

Rare

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10
Q

If bilateral adrenal tumors are present, how will they present?

A

Nonfunctional on one side and pheochromocytoma of opposite adrenal

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11
Q

What test do ALL suspect cushingoid dogs have performed?

A

Urine culture

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12
Q

How do you dx hyperadrenocorticism?

A

LDDST

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13
Q

How does dexamethasone administration affect a normal dog?

A

Normally decreases ACTH

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14
Q

No suppression at 8h on a LDDST indicates what disease?

A

Hyperadrenocorticism (Cushing’s)

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15
Q

How do you ddx PDH from AT?

A

No suppression @ 8h + 50% suppression @ 4h = PDH

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16
Q

What is the test of choice for iatrogenic Cushings/Addison’s?

A

ACTH stim test

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17
Q

How does ketoconazole help treat hyperadrenocorticism (Cushing’s)?

A

Decreases circulating cortisol concentrations

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18
Q

Synthetic steroid that inhibits cortisol and aldosterone but can cause hyperK

A

Trilostane

19
Q

This drug helps dogs “pee in the right places” but doesn’t necessarily treat Cushing’s

A

Anipryl

20
Q

What is the treatment of choice for AT Cushing’s?

A

Adrenalectomy (commonly done in ferrets)

21
Q

What % of adrenal tumors are mineralized/metastasized?

A

50%

22
Q

Increased ALP and cholesterol with decreased USG + proteinuria might indicate what disease?

A

Hyperadrenocorticism (Cushing’s)

23
Q

Dogs with PU/PD and weight loss likely have what endocrinopathy?

A

Hyperglycemia (DM)

24
Q

What is the most common reason that DM dogs present to the vet?

A

Needing to pee at night or pee in the house

25
Q

Plantigrade stance is associated with which endocrinopathy?

A

Hyperglycemia (DM)

26
Q

Which endocrinopathy can cause cataracts?

A

Hyperglycemia (DM)

27
Q

How can you ddx DM and Cushings in dogs with PU/PD?

A

DM includes weight loss

28
Q

What is the main clinical sign of hyperPTH/hyperCa?

A

PU/PD

29
Q

What is the goal of hypoPTH/hypoCa therapy?

A

Maintain low normal Ca+2 levels (8-10mg/dL)

30
Q

Why do you not want to provide Ca supplementation prior to parturition?

A

Makes eclampsia worse

31
Q

What type of DM is more common in cats?

A

Type 2 (insulin resistance and beta cell burnout)

32
Q

What type of DM is more common in dogs?

A

Type 1 (failure of beta cells to produce insulin)

33
Q

What are factors that can predispose to insulin resistance?

A

Obesity, chronic DM, other endocrinopathies

34
Q

What test can you to if you’re unsure if hyperglycemia is d/t DM?

A

Fructosamine

35
Q

How will e-lytes be affected in an animal with DM?

A

All out of whack

36
Q

What type of insulin do you want to use for DKA patients?

A

Short-acting

37
Q

Can DM remission occur?

A

Only in cats and only 20-40% of the time

38
Q

What value is considered “insulin resistance”?

A

Dose >2 IU/kg

39
Q

What are ddx for hyperCa?

A

HARDIONS (hyperPTH, Addison’s, renal failure, hyperVit D, idiopathic hyperCa of cats, osteolysis, neoplasia, spurious)

40
Q

What test can you use to measure glucose regulation over the last 6-9wk?

A

GHb

41
Q

A fructosamine test assesses glycemic control over the last _____

A

2-3wk

42
Q

What does a glucose curve show?

A

Peak insulin activity (should bottom out @6h)

43
Q

What is the rule of thumb for initiating insulin therapy?

A

Start low, go slow