Clin Path Review 4 Flashcards
When does a regenerative anemia d/t blood loss NOT have normal RBC morphology?
Hemangiosarcoma in dogs
Does blood loss cause thrombocyotopenia?
NO NO NO
What is the most common way in which blood is chronically lost?
Via intestine
Microcytosis, keratocytes, regenerative anemia, low serum iron
Iron deficiency anemia
How will iron storage differ with anemia of inflammatory disease?
High serum iron
What causes extravascular hemolysis?
Phagocytosis of RBCs in spleen, liver, etc
What diseases cause extravascular hemolysis?
IMHA, heinz body anemia, RBC parasites, hypophosphatemia
What are signs of blood destruction?
Anemia, splenomegaly, normal TP
IMHA is assoc. w/what in horses?
Penicillin, Clostridium, neoplasia
IMHA is assoc. w/what in cats?
Mycoplasma, FeLV, neoplasia
Which dog breed is at highest risk for IMHA?
Cocker spaniels
Thrombocytopenia, inflammatory leukogram, azotemia, Spherocytes
IMHA
Spherocytes can be seen in horses with what infection?
Clostridial infections
What do IMHA animals usually die of?
Thromboembolism
How do you treat IMHA?
Glucocorticosteroids, fluids
Direct antiglobulin test done to detect IMHA as long as agglutination is not present
Coomb’s test
Maternal antibodies against neonate’s blood group antigen
Neonatal isoerythrolysis
Which erythrocyte parasites cause intravascular hemolysis?
Babesia and Theileria
Common, serous cause of severe anemia in cats that is transmitted horizontally and vertically
Mycoplasma haemofelis
How do you treat Mycoplasma haemofelis infection?
Doxycycline for 3 weeks
Causes severe anemia in baby pigs and is assoc. w/poor weight gain in adult pigs
Mycoplasma haemosuis
How do you treat baby pigs with M. haemosuis?
Long-acting oxytetracycline
Tick-borne rickettsial infection that can cause fatal hemolytic anemia d/t immune-mediated destruction
Anaplasmosis
Causes severe disease and hemolytic anemia and is commonly mistaken for IMHA
Babesiosis
How do you treat Babesiosis?
Imidocarb disproprionate
Protozoans that cause hemolytic anemia in ruminants
Theileriosis
Piroplasm lives in RBCs of ruminants
Theileriosis
Protozoan of cats transmitted by ticks and almost always fatal
Feline cytauxzoonosis
What stain will dx heinz body anemia?
Wright’s stain and New Methlyne Blue stain
Moth ball ingestion causes what type of anemia?
Heinz body anemia
How do you treat methemoglobinemia?
Methylene blue
Caused by red maple leaf ingestion in horses and nitrite poisoning in cows
Methemoglobinemia
Causes postparturient hemoglobinuria in cattle, DM in cats
Copper toxicosis
What causes yellow lamb disease?
C. perfringins type A
What causes bacillary hemoglobinuria and red water disease in cattle?
C. haemolyticum
English springer spaniels can have an autosomal recessive genetic disorder causing _____ deficiency that causes hemolytic anemia
Phosphofrutokinase
What dog breeds are genetically predisposed to pyruvate kinase deficiency?
Basenji, beagle, westie, Carin terriers
What cat breeds are genetically predisposed to pyruvate kinase deficiency?
Abyssinian, Somali, DSH
