Clin Path Review

Question 1

Measure time for fibrin clot formation

Answer 1

aPTT and Activated Clotting Time

Question 2

Requires 70% deficiency of any factor before prolongation is detected

Answer 2

aPTT, PT

Question 3

Which clotting time measurement is more senstive?

Answer 3

aPTT

Question 4

Requires 95% deficiency of factor before prolongation is detected

Answer 4

ACT

Question 5

What factor is deficient if PT (extrinsic/common pathway) is increased?

Answer 5

Factor 7

Question 6

Why is PT a good screening test for Vit K deficiency?

Answer 6

Short half life of factor 7

Question 7

What are Vit K dependent clotting factors?

Answer 7

Factor 2, 7, 9, 10

Question 8

Inhibit platelet function and fibrin polymerization when pathologically increased

Answer 8

Fibrin degradation products

Question 9

When might FDPs be pathologically increased?

Answer 9

DIC

Question 10

Mycotoxin from moldy sweet clover

Answer 10

Warfarin

Question 11

Bleeding/shock with regenerative anemia and a normal platelet count indicate what toxicity?

Answer 11

Warfarin/moldy sweet clover

Question 12

Hemorrhage causes what kind of anemia?

Answer 12

Regenerative

Question 13

What is the result of continued activation of coagulation and fibrinolysis?

Answer 13

Microvasculature thrombosis, depletion of coag factors = bleeding

Question 14

What causes DIC via induction/exposure of tissue factor?

Answer 14

Sepsis, tissue necrosis, neoplasia

Question 15

What proteolyic enzymes can cause DIC?

Answer 15

Snake venoms, trypsin released during pancreatitis

Question 16

Which phase of DIC is characterized by thrombosis and ischemic necrosis and organd dysfunction?

Answer 16

Hypercoagulable (1st) phase

Question 17

What phase of DIC is characterized by consumption of PLTs, coag factors, and AT, and bleeding?

Answer 17

Consumptive (2nd) phase

Question 18

Mucosal bleeding is assoc. w/which aspect of the consumption phase of DIC?

Answer 18

Platelet consumption

Question 19

Hemorrhage is assoc. w/which aspect of the consumption phase of DIC?

Answer 19

Factor consumption

Question 20

What must you always do prior to biopsy of the liver?

Answer 20

Screen for coag abnormalities

Question 21

What are inherited factor deficiencies?

Answer 21

Hemophilia A and V

Question 22

Which coag factor is assoc. w/Hemophilia A?

Answer 22

Factor 8

Question 23

Which coag factor is assoc. w/Hemophilia V?

Answer 23

Factor 9

Question 24

Suspected in a young animal with a bleeding disorder

Answer 24

Inherited factor deficiency

Question 25

X-linked recessive inheritance in dogs and cattle that causes mild to severe bleeding

Answer 25

Hemophilia A

Question 26

Characterized by normal PLT count and PT, prolonged aPTT, and reduced % of factor activity

Answer 26

Hemophilia A (factor 8)

Question 27

Hageman’s disease is a factor _____ deficiency seen in which species?

Answer 27

Factor 12 seen in cats

Question 28

Which inherited factor deficiency is NOT assoc. w/bleeding?

Answer 28

Hageman’s disease