Clin Path Review Flashcards
Measure time for fibrin clot formation
aPTT and Activated Clotting Time
Requires 70% deficiency of any factor before prolongation is detected
aPTT, PT
Which clotting time measurement is more senstive?
aPTT
Requires 95% deficiency of factor before prolongation is detected
ACT
What factor is deficient if PT (extrinsic/common pathway) is increased?
Factor 7
Why is PT a good screening test for Vit K deficiency?
Short half life of factor 7
What are Vit K dependent clotting factors?
Factor 2, 7, 9, 10
Inhibit platelet function and fibrin polymerization when pathologically increased
Fibrin degradation products
When might FDPs be pathologically increased?
DIC
Mycotoxin from moldy sweet clover
Warfarin
Bleeding/shock with regenerative anemia and a normal platelet count indicate what toxicity?
Warfarin/moldy sweet clover
Hemorrhage causes what kind of anemia?
Regenerative
What is the result of continued activation of coagulation and fibrinolysis?
Microvasculature thrombosis, depletion of coag factors = bleeding
What causes DIC via induction/exposure of tissue factor?
Sepsis, tissue necrosis, neoplasia
What proteolyic enzymes can cause DIC?
Snake venoms, trypsin released during pancreatitis
Which phase of DIC is characterized by thrombosis and ischemic necrosis and organd dysfunction?
Hypercoagulable (1st) phase
What phase of DIC is characterized by consumption of PLTs, coag factors, and AT, and bleeding?
Consumptive (2nd) phase
Mucosal bleeding is assoc. w/which aspect of the consumption phase of DIC?
Platelet consumption
Hemorrhage is assoc. w/which aspect of the consumption phase of DIC?
Factor consumption
What must you always do prior to biopsy of the liver?
Screen for coag abnormalities
What are inherited factor deficiencies?
Hemophilia A and V
Which coag factor is assoc. w/Hemophilia A?
Factor 8
Which coag factor is assoc. w/Hemophilia V?
Factor 9
Suspected in a young animal with a bleeding disorder
Inherited factor deficiency
X-linked recessive inheritance in dogs and cattle that causes mild to severe bleeding
Hemophilia A
Characterized by normal PLT count and PT, prolonged aPTT, and reduced % of factor activity
Hemophilia A (factor 8)
Hageman’s disease is a factor _____ deficiency seen in which species?
Factor 12 seen in cats
Which inherited factor deficiency is NOT assoc. w/bleeding?
Hageman’s disease
