Clin Path Review 5

Question 1

What causes hemorrhage?

Answer 1

Decreased PLT #/ function, decreased coag factor/function

Question 2

Inability to form a thrombus =

Answer 2

Hemorrhage

Question 3

What is the avg lifespan of a canine platelet (and feline platelet)?

Answer 3

5-10d (shorter in cats)

Question 4

1/3 of PLT mass lives in which organ?

Answer 4

Spleen

Question 5

Platelet adhesion requires what factor?

Answer 5

Von Willebrand facto

Question 6

What electolyte is required for PLT aggregation?

Answer 6

Calcium

Question 7

PLT count lower than reference interval

Answer 7

Thrombocytopenia

Question 8

Patients are at risk for spontaneous hemorrhage when PLT count is ______

Answer 8

<30k

Question 9

How do platelets affect bleeding tests?

Answer 9

Prolonged w/decreased PLT #/function

Question 10

Mucosal bleeding, petechia, hemorrhagic anemia

Answer 10

Thrombocytopenia

Question 11

What causes thrombocytopenia?

Answer 11

Decreased PLT production, destruction, sequestration, loss, consumption

Question 12

What causes decreased PLT production?

Answer 12

BM hypoplasia, neoplasia

Question 13

What causes PLT destruction

Answer 13

ITP

Question 14

Bleeding from mucous membranes, maybe anemia, normal coag tests, normal biochem

Answer 14

ITP

Question 15

What causes PLT sequestration?

Answer 15

Hepatomegaly, spleinic torsion/neoplasia, endotoxic shock, severe hypothermia

Question 16

What causes PLT consumption?

Answer 16

DIC, vasculitis (rickettsial dz, FIP)

Question 17

Is thrombocytosis usually primary or secondary?

Answer 17

Secondary

Question 18

What can cause thrombocytosis in horses?

Answer 18

Splenic contraction

Question 19

What endocrine disease can cause thrombocytosis?

Answer 19

Hypoadrenocorticism

Question 20

What dog breed is predisposed to vWD?

Answer 20

Doberman pinchers

Question 21

Normal PLT but decreased PLT adhesion

Answer 21

Von Willebrand’s Disease

Question 22

Congenital macrothrombocytopenia is a genetic mutation in which dog breed?

Answer 22

Cavalier King Charles Spaniels

Question 23

Where is albumin synthesized?

Answer 23

Liver

Question 24

What two major roles does albumin play?

Answer 24

Transport protein, osmotic pressure

Question 25

Proteins that respond to inflammation

Answer 25

Acute phase proteins

Question 26

Is albumin a positive or negative acute phase protein and what does this mean?

Answer 26

Negative, decreases inflammation

Question 27

Panhyperproteinemia is usually due to waht?

Answer 27

Dehydration

Question 28

Panhypoproteinemia can be caused by what two things?

Answer 28

Blood loss and PLE

Question 29

Decreased production of albumin is caused by what?

Answer 29

Inflammation (or maybe liver or GIT issues)

Question 30

If albumin is increased, what is the cause?

Answer 30

Dehydration

Question 31

Caused by SCIDS, hemorrhage, PLE, or failure of passive transfer

Answer 31

Hypoglobulinemia

Question 32

Monoclonal gammopathy indicates what disease process?

Answer 32

Neoplasia

Question 33

Polyclonal gammopathy indicates what disease process?

Answer 33

Inflammation