Endocrine & Hematologic Emergencies Flashcards
A communication system that controls functions inside the body
Endocrine system
The endocrine system maintains the body’s ___
Homeostasis
___ secrete messenger hormones
Endocrine glands
Chemical substances produced by a gland
Hormone
Hormones travel through the ___ to the end organs, tissues, or cells that they are intended to affect
Blood
When the hormone arrives, the cell, tissue, or organ ___
Receives the message and an action or cellular process takes place
Endocrine disorders are caused by ___
An internal communication problem
Hypersecretion
Produce more hormone than is needed
Hyposecretion
Produce less hormone than is needed
Two things the brain needs to survive
Glucose and oxygen
Necessary for glucose to enter the cells for metabolism
Insulin
Two hormones produced and stored by the pancreas that play a major role in glucose metabolism
- Glucagon
- Insulin
The islets of Langerhans in the pancreas is filled with ___
Alpha and beta cells
The alpha cells in the islets of Langerhans produce ___
Glucagon
The beta cells in the islets of Langerhans produce ___
Insulin
In a person without diabetes, the pancreas stores and secretes insulin and glucagon in response to ___
The level of glucose in the blood
When a person eats, the level of glucose in the blood ___
Rises
When the level of glucose in the blood rise, the pancreas ___
Secretes insulin into the blood
When the pancreas secretes insulin into the blood, this allows ___
The glucose to enter the body’s cells and be used for energy. Also allow glucose to be stored in the form of glycogen in the liver and skeletal muscles for use at a later time
If a hungry person skips a meal, ___
A message is sent to the pancreas to secrete glucagon, which stimulates the liver and skeletal muscles to release glycogen and converts it back to glucose to be used as cellular fuel
A disorder of glucose metabolism, such that the body has an impaired ability to get glucose into the cells to be used for energy
Diabetes mellitus
The patient with diabetes has either ___
- Impaired insulin production
- Not enough functional receptors on the surface of the cells for the insulin to bind to
Three types of diabetes
- Diabetes mellitus type 1
- Diabetes mellitus type 2
- Pregnancy-induced gestational diabetes
A state in which the blood glucose level is above normal
Hyperglycemia
A state in which the blood glucose level is below normal
Hypoglycemia
Patients with severe ___ are more likely to have a depressed level of consciousness than patients with ___
- Hypoglycemia
- Hyperglycemia
Altered mental status related to diabetic emergencies can often mimic ___
Alcohol intoxication
___ can develop if a person with diabetes takes their medications as prescribed but fails to eat enough food
Hypoglycemia
All hypoglycemic patients require prompt treatment with ___
Oral glucose paste (if alert and able to protect airway), or injection of glucose (dextrose) or glucagon by an ALS provider
Blood glucose level below 50 mg/dL
Hypoglycemic crisis
Blood glucose level between 50 and 80 mg/dL
Hypoglycemia
Blood glucose level between 80 and 120 mg/dL
Normal
Blood glucose level between 120 and 400 mg/dL
Hyperglycemia
Blood glucose level above 400 mg/dL
DKA, HHNS, or symptomatic hyperglycemia
Onset of hyperglycemia
Gradual (hours to days)
Onset of hypoglycemia
Rapid (within minutes)
Skin with hyperglycemia
Warm and dry
Skin with hypoglycemia
Pale, cool, and moist
Infection rate with hyperglycemia
Common
Infection rate with hypoglycemia
Uncommon
Thirst with hyperglycemia
Intense
Thirst with hypoglycemia
Absent
Hunger with hyperglycemia
Present and increasing
Hunger with hypoglycemia
Absent
Vomiting/abdominal pain with hyperglycemia
Common
Vomiting/abdominal pain with hypoglycemia
Uncommon
Breathing with hyperglycemia
With DKA there are rapid, deep (Kussmaul) respirations
Breathing with hypoglycemia
Normal; may become shallow or ineffective if hypoglycemia is severe and mental status is depressed
Odor of breath with hyperglycemia
With DKA there may be a sweet fruity odor
Odor of breath with hypoglycemia
Normal
BP with hyperglycemia
Normal to low
BP with hypoglycemia
Normal to low
Pulse with hyperglycemia
Rapid, weak, and thready
Pulse with hypoglycemia
Rapid, weak
Consciousness with hyperglycemia
Restlessness, possibly progressing to coma; abnormal or slurred speech; unsteady gait
Consciousness with hypoglycemia
Irritability, confusion, seizure, or coma; unsteady gait
Response to treatment with hyperglycemia
Gradual, within 6 to 12 hours following medical treatment
Response to treatment with hypoglycemia
Immediate improvement after administration of glucose
An autoimmune disorder in which the individual’s immune system produces antibodies against the pancreatic beta cells
Type 1 diabetes
Always ask about an ___ in patients with type 1 diabetes
Insulin pump
A patient with new-onset type 1 diabetes will have these symptoms related to eating and drinking
- Polyuria
- Polydipsia
- Polyphagia
- Weight loss
- Fatigue
More frequent urination
Polyuria
Why does type 1 diabetes cause polyuria
Excess glucose in the blood overwhelms the kidney’s filtration and glucose spills into the urine. This causes more water to be pulled out of the bloodstream into the urine
An increase in fluid consumption
Polydipsia
Polydipsia can lead to ___
Severe electrolyte abnormalities
Why does type 1 diabetes lead to polydipsia
Polyuria leads to dehydration and increased thirst
Increased food intake
Polyphagia
When the body burns fat instead of glucose, ___ is produced
Acid waste
The acids produced from burning fat instead of glucose
Ketones
What causes Kussmaul respirations with type 1 diabetes?
The ketone levels in the blood increase and spill into the urine with the excess glucose. When the kidneys are saturated with glucose and ketones they do not work properly to maintain the acid-base balance in the body. The body responds with a backup system by breathing faster and deeper to release more acid via CO2 in the lungs
If fat metabolism and ketone production continue, ___ can develop in patients with diabetes
Diabetic ketoacidosis (DKA)
DKA
Diabetic ketoacidosis
DKA may present as ___
Generalized illness accompanied by:
1. Abdominal pain
2. Body aches
3. Nausea
4. Vomiting
5. Altered mental status or unconsciousness (if severe)
Caused by a resistance to the effects of insulin at the cellular level
Type 2 diabetes
Obesity predisposes patients to ___ diabetes
Type 2
The blood glucose levels begin to rise and do not respond when the pancreas secretes insulin
Insulin resistance
Test to estimate the average blood glucose level over time taken at the doctor several times a year
A1C
Occurs when blood glucose levels are very high
Symptomatic hyperglycemia
Early signs and symptoms of symptomatic hyperglycemia
- Frequent urination
- Increased thirst
- Blurred vision
- Fatigue
If the high blood glucose levels go untreated, the patient may present with ___
- A fruity odor on the breath
- Nausea and vomiting
- Shortness of breath
- Dry mouth
- Weakness
- Altered mental status
Type 1 diabetes hyperglycemia leads to ketoacidosis and dehydration from ___
Excessive urination
Type 2 diabetes hyperglycemia leads to a state of dehydration due to ___
The discharge of fluids through all body systems and eventually out through the kidneys
Type 2 diabetes hyperglycemia induced dehydration leads to ___
Hyperosmolar hyperglycemic nonketotic syndrome (HHNS)
HHNS
Hyperosmolar hyperglycemic nonketotic syndrome
Secondary consequences of prolonged hyperglycemia
- Wounds that do not heal
- Numbness in the hands and feet
- Blindness
- Renal failure
- Gastric motility problems
When blood glucose levels are not controlled in diabetes type 2, ___ can develop
HHNS
HHNS can present similarly to the ___ seen in patients with type 1 diabetes
DKA
The onset of HHNS is commonly associated with ___
A profound infection or illness
Key signs and symptoms of HHNS
- Hyperglycemia
- Altered mental status, drowsiness, lethargy
- Severe dehydration, thirst, dark urine
- Visual or sensory deficits
- Partial paralysis or muscle weakness
- Seizures
Very concentrated blood as a result of relative dehydration
Hyperosmolarity
In HHNS the patient cannot drink enough fluids to keep up with the ___
Exceedingly high glucose levels in the blood
As HHNS progresses, the urine becomes ___
Rather dark and concentrated
An acute emergency in which a patient’s blood glucose level drops and must be corrected swiftly
Symptomatic hypoglycemia
Hypoglycemia develops much more ___ than hyperglycemia
Quickly
Common patient or caregiver causes of the development of low blood glucose levels
- Correct dose of insulin with a change in routine
- More insulin than necessary
- A correct dose of insulin without the patient eating enough
- Correct does of insulin and and acute illness developed in the patient
Signs and symptoms of hypoglycemia
- Normal to shallow or rapid respirations
- Pale, moist, skin
- Diaphoresis
- Dizziness, headache
- Rapid pulse
- Normal to low blood pressure
- Altered mental status (aggressive, confused, lethargic, or unusual behavior)
- Anxious or combative behavior
- Seizure, fainting, coma
- Weakness on one side of body (may mimic stroke)
- Rapid changes in mental status
You must have a high index of suspicion for a ___ when you encounter a child who has an altered mental status or depressed LOC
Low glucose level
If the patient has eaten but has not taken insulin, it is more likely that ___ is developing
Hyperglycemia
If the patient has taken insulin but has not eaten, the problem is more likely to be ___
Hypoglycemia
Questions to ask a patient known to have diabetes
- Do you take insulin or any pills that lower your blood sugar?
- Do you wear an insulin pump and is it working properly?
- Have you taken your usual dose of insulin or pills today?
- Have you eaten normally today?
- Have you had any illness, unusual amount of activity, or stress?
When you suspect a diabetes-related problem, the secondary assessment should focus on the patient’s ___
Mental status and ability to swallow, and protect the airway
With a diabetic patient, obtain a ___ to track the patient’s neurologic status
Glasgow Coma Scale Score
The blood glucose level in neonates should be ___
Above 70 mg/dL
Base your administration of glucose on ___
Serial glucose readings
If a glucometer is not available, a ___ indicates that you need to provide more glucose
Deteriorating LOC
If the patient is hypoglycemic, conscious, and able to swallow without the risk of aspiration, ___
Encourage them to take glucose tablets. If not available, household sources of glucose may be used
If the patient is hypoglycemic and unconscious or unable to swallow without the risk of aspiration, ___
The patient will need IV glucose, or IM or IN glucagon (most EMTs are not able to give)
A patient with symptomatic hypoglycemia needs ___
Glucose immediately
A patient with symptomatic hyperglycemia needs ___
Insulin and IV fluid therapy, prompt transport to the hospital
When in doubt if the patient is in symptomatic hyperglycemia or symptomatic hypoglycemia, most protocols will err on the side of ___
Giving glucose
Most common type of oral glucose preparation for EMS providers
Rapidly dissolving gel
Three types of oral glucose preparations available commercially
- Rapidly dissolving gel
- Large chewable tablet
- Liquid formulation
You should administer ___ to any patient with a decreased LOC who has a history of diabetes
Glucose gel
Contraindications for oral glucose
Inability to swallow and unconsciousness
How to administer glucose gel
- Obtain an online or offline order
- Open the pouch
- Squeeze the glucose under the tongue or into the buccal space
- Have the patient swallow
If the patient’s mental status, vital signs, and blood glucose level become normal after administering glucose, encourage the patient to ___
Eat a meal or snack containing carbohydrates and protein
Mnemonic to remember conditions that can lead to an altered mental status
AEIOU-TIPS
AEIOU-TIPS
-Alcohol
-Epilepsy, endocrine, electrolytes
-Insulin
-Opiates and other drugs
-Uremia
-Trauma, temperature
-Infection
-Poisoning, psychogenic causes
-Shock, stroke, seizure, space-occupying lesion, subarachnoid hemorrhage
The study of blood-related diseases
Hematology
Four components of blood
- Erythrocytes (red blood cells)
- Leukocytes (white blood cells)
- Platelets
- Plasma
RBCs
Red blood cells
WBCs
White blood cells
RBCs make up how much of the total blood volume?
42% to 47%
RBCs contain a protein called ___
Hemoglobin
The hemoglobin carries ___ of the oxygen in the blood and some of the CO2
97%
WBCs make up ___ of the total blood cell volume
0.1% to 0.2%
WBCs collect ___ and provide for their ___
- Dead cells
- Correct disposal
Platelets make up ___of the blood cell volume
4% to 7%
An inherited blood disorder that affects the RBCs
Sickle cell disease
Sickle disease is also called ___
Hemoglobin S disease
Serves as the transportation medium for all blood component as well as proteins and minerals
Plasma
The sickle cell protects individuals from contracting ___
Malaria
Sickle cell disease is common among people of ___ ancestry
African, Caribbean, and South American
The sickle cell shape leads to dysfunction in ___
Oxygen binding and unintentional clot formation
The inintentional clots from sickle cells may result in a blockage called ___
Vasoocclusive crisis
Lifespan of normal RBCs
110 to 120 days
Sickle cells shorter lifespan leads to ___
More cellular waste products in the blood, contributing to sludging of the blood
Maintaining ___ is important to patients with sickle cell disease
Hydration
Complications associated with sickle cell disease
- Anemia
- Gallstones
- Jaundice
- Splenic dysfunction
- Vascular occlusion with ischemia
Hemophilia mostly affects ___
Males
Males inherit hemophilia from their ___
Mother, but only if the mother’s father has hemophilia and their mother is also a carrier
Decreased ability to create a clot after an injury
Hemophilia
In a healthy person a clot will begin to form ___
Within 13 seconds for a small cut and not longer than about 7 minutes for a more serious injury
Common complications of hemophilia A
- Long-term joint problems
- Bleeding in the brain
- Thrombosis due to treatment
A disorder in the body’s ability to maintain the viscosity and smooth flow of blood through the venous and arterial systems
Thrombophilia
The concentration of particular elements in the blood creates what amounts to clogging or blockage issues
Thrombophilia
General term for many different conditions that result in blood clotting more easily than normal
Thrombophilia
DVT
Deep vein thrombosis
DVT is a common medical problem in ___
Sedentary patients and an patients who have had recent injury or surgery
DVT is a particularly worrisome risk for patients who have had ___
Joint replacement surgery
If DVT develops in an individual, ___ may be administered
Anticoagulation therapy may be administered
An abnormally low number of RBCs
Anemia
Each hemoglobin molecule can carry how much oxygen?
4 molecules
Anemia may be the result of ___
- Chronic or acute bleeding
- Deficiency in certain vitamins or minerals
- Underlying disease process
Hypoxia from anemia
Hypoxemia hypoxia
Additional questions to ask a patient with known sickle cell disease
- Have you had a crisis before?
- When was the last time you had a crisis?
- How did your last crisis resolve?
- Have you had any illness, unusual amount of activity, or stress lately?