ENDO-EoB Flashcards

1
Q

Which of the following statements is most accurate for LH?

A.it is produced by the corpus luteum and helps prepare the endometrium for a possible implantation

B.It plays a more important role than FSH initiation of spermatogenesis from spermatocytes in the Sertoli cells of the testes in males

C. It plays a critical role in stimulating testosterone production by the Sertoli cells of the testes

D. Its surge triggers ovulation and initiates the conversion of the residual follicle into of a corpus luteum

E. It is produced by the hypothalamus during puberty

A

D

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2
Q

The main site for the adiponectin synthesis is?

A. Brown adipose tissue

B. Fibroblast

C. Immune cells

D. skeletal muscle cells

E. White adipose tissue

A

E

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3
Q

Which of the following is responsible for the production of androgens from cholesterol?

A. Epidermis

B. Leydig cells

C. primordial germ cells

D. seminal vesicles

E. sertoli cells

A

B

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4
Q

A 24 year old man complains of weight loss, excessive sweating, palpitations and increased anxiety. There is a family history of thyroid disease. Which of the following results would suggest primary hyperthyroidism?

A. High serum TSH, high serum free thyroxine, high serum free triiodothryonine

B. High serum TSH, high serum free thyroxine, low serum free triiodothyronine

C. High serum TSH, low serum free thyroxine, low serum free triiodothyronine

D. Low serum TSH, high serum free thyroxine, high serum free triiodothryronine

E. Low serum TSH, low serum free thyroxine, low serum free triiodothyronine

A

D

feedback loops are important in regulation of thyroid function
In primary hyperthyroidism, the thyroid gland is producing excess thyroxine and tri-iodothyronine, this will suppress TSH production

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5
Q

Which of the following causes the production of the second messenger cAMP?

A. Activation of adenyl cyclase

B. Activation catalase

C. Activation of protease

D. Activation of steroid hormone receptors

E. Activation protein kinase A

A

A

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6
Q

Which recess marks the embryonic opening of the thyroglossal duct?

A. foramen cecum

B. foramen lacerum

C. foramen ovale

D. foramen rotundum

E. foramen spinosum

A

A

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7
Q

Leptin regulates food intake through interactions with

A. brown adipose tissue

B. fibroblasts

C. the hypothalamus

D. the pancreas

E. white adipose tissue

A

C

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8
Q

LH stimulates steroidogenesis to make this substance from cholesterol

A. acetate

B. albumin

C. aromatase

D. androgen

E. pregnenolone

A

E

is first step in synthesis of steroid hormones

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9
Q

Which of the following statements is most accurate for Anti-diuretic hormone (ADH)?

A. a decrease in plasma osmolality is a stimulus for release of ADH

B. ADH dilates the blood vessels and reduced blood pressure

C. ADH inhibits the water channels (aquaporins) located on the membrane of the cells of the collecting ducts of the kidney, allowing water to be lost in the urine

D. ADH is synthesised in the posterior pituitary gland

E. Neurosecetory cells of the hypothalamic nuclei are the main sources of ADH in our body

A

E

ADH released from posterior pituitary but synthesised in neurosecretory cells in arcuate nucleus of hypothalamus

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10
Q

The main stimulus fro the production of aldosterone is

A. increased ACTH

B. increased ADH

C. increased angiotensin 2

D. increased blood pressure

E. reduced renin

A

C

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11
Q

This hormone inhibits the release of growth hormone from the anterior pituitary gland

A. corticotrophin releasing hormone (CRH)

B. Dopamine

C. prolactin

D. somatostatin

E. vasopressin

A

D

somatostatin is the main inhibitor of GH release

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12
Q

This hormone peaks in the luteal phase of the menstrual cycle

A. cortisol

B. estrogen

C. insulin

D. progesterone

E. prolactin

A

D

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13
Q

The pituitary:

A. contains anterior and posterior lobes which receive their blood supply by the inferior hypophyseal branches of the internal carotid arteries

B. is connected to the hypothalamus via the infundibulum (pituitary stalk)

C.is not in anatomical proximity to the internal carotid arteries

D. Lies above the cavernous sinuses bilaterally

E. Lie above the optic chiasm

A

B

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14
Q

Which of the following disorders is characterised principally by a hormone deficiency?

A. acromegaly

B. Addison’s disease

C. Cushing’s disease

D. glucagonoma

E. Phaeochromocytoma

A

B

Addison’s is cortisol deficiency

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15
Q

Glucagon is released by

A. alpha cells of the pancreatic islets

B. beta cells of pancreatic islets

C. delta cells of pancreatic islets

D. pancreatic ductal cells

E. PP cells of pancreatic islets

A

A

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16
Q

Which glucose transporter mediates insulin-sensitive uptake of glucose into muscle cells?

A. GLUT1

B. GLUT2

C. GLUT3

D. GLUT4

E. insulin receptor substrate-1 (IRS-1)

A

D

17
Q

The main storage form of glucose in the body is:

A. glucagon

B. glucose-6-phosphate

C. glycogen

D. hexokinase

E. pyruvate

A

C

18
Q

Dopamine inhibits the release of this hormone

A. cortisol

B. insulin

C. parathyroid hormone

D. progesterone

E. prolactin

A

E

19
Q

Which of the following hormones stimulates insulin release?

A. adrenaline

B. cortisol

C. glucagon

D. glucagon-like peptide 1

E. growth hormone

A

D

is an incretin hormone-acts on the pancreas beta cells to stimulate insulin secretion after meals

20
Q

This hormone regulates circulating calcium levels

A. anti-diuretic hormone (vasopressin)

B. cortisol

C. glucagon-like peptide 1 (GLP-1)

D. parathyroid

E. progesterone

A

D

21
Q

Which cells produce renin?

A. cells of the macula densa

B. interstitial fibroblasts

C. macrophages

D. podocytes

E. the juxtaglomerular cells

A

E

22
Q

G- protein coupled receptors are the site of interaction for which of the following?

A. catecholamines

B. cholecalciferol

C. corticosteroids

D. insulin

E. thyroxine

A

A

23
Q

Which of the following is a hormone precursor primarily produced by the skin?

A. cortisol

B. glucagon-like peptide-1 (GLP-1`)

C. parathyroid hormone

D. progesterone

E. vitamin D

A

E

produced in the skin from the cholesterol under the influence of UV light

24
Q

Which of the following hormones can penetrate the plasma membrane?

A. adrenaline

B. estrogen

C. glucagon

D. Insulin

E. parathryroid hormone

A

B

is a steroid hormone-lipid soluble