Drugs, Driving, Side effects Flashcards
What are the drugs with driving warnings?
Sedating drugs, effects increased by alcohol
Antihistamines Antiepileptic Antipsychotics Opioids TCA Baclofen Hypnotics Benzodiazepines Quinolones Selegiline Apomorphine Levodopa
What drugs cause hypotension?
Alpha blockers
Dopamine receptor agonists
What drugs cause hypoglycaemia?
Sulphonylureas
Insulin
What is an adverse drug reaction?
Unwanted or harmful reaction experienced following the administration of a drug, combination of drugs under normal conditions of use which is suspected to be relayed to the drug
When do you report adverse drug reactions?
Newer drugs and vaccines
Medication errors
Medical devices
Defective medicine or suspected fake medicines
What drugs cause oral ulcers?
ACEi NSAID Nicorandil Pancreatin Cytotoxic
What drugs cause oral candidiasis?
Corticosteroid inhalers
What drugs cause staining of teeth?
Chlorhexidine (brown)
Liquid iron (black)
Tetracyclines (yellow + grey)
What drugs cause osteonecrosis of the jaw?
Bisphosphonates
What drugs cause gingival hypertrophy?
Ciclosporin
Nifedipine
Phenytoin
What drugs cause dry mouth?
Antimuscarinics Antipsychotics Opioids Excessive diuretics Antihistamines Antidepressants
What drugs cause taste disturbance?
ACEi Amiodarone Carbimazole Clarithromycin Lithium Metformin Metronidazole Zopiclone
What are the drugs that cause myelosuppression?
DMARDs - methotrexate, penicillamine, gold
Antiepileptics - carbamazepine, ethosuximide, lamotrigine, phenytoin
Antibiotics- linezolid, chloramphenicol, dapsone, co-trimoxazole, trimethoprim
Immunosuppressants- azathioprine, cytotoxics
Antifolates - phenytoin, methotrexate, trimethoprim
Others - aminosalicylates, carbimazole, clozapine, mirtazapine
What are the symptoms of myelosuppression?
Low blood count
Susceptible to infection
Anaemia
Thrombocytopenia
What are the drugs that cause photo sensitisation?
Antifungals - voriconazole
Tetracyclines- doxycycline, demeclocycline
Co-trimoxazole, quinolones (oxacins)
Hydroxychloroquine, chloroquine
Amiodarone PhenothiazineS Tacrolimus Topical NSAIDs Benzoyl peroxide Isotretinoin Vitamin A
What drugs cause contact sensitisation?
Methotrexate
Chlorpromazine
Cytotoxics
What drugs cause QT prolongation?
Antipsychotics- pimozide, haloperidol, quetiapine
Antidepressants- citalopram/escitalopram, TCA, venlafaxine
Anti-arrhythmics - sotalol, amiodarone
CNS - methadone, lithium, triptans, apomorphine, ondansetron, domperidone, metoclopramide, quinine
Macrolides, hydroxychloroquine, chloroquine, quinolone, ketoconazole, itraconazole
What are the predisposing factors for QT prolongation?
Increasing age Female Cardiac disease Bradycardia Electrolyte disturbances
What are the drugs that cause hypokalaemia?
Loop/thiazide diuretics Corticosteroids Beta 2 agonist Theophylline Stimulant laxatives Amphotericin B
What are the drugs that increase the risk of bleeding?
Anti platelets - NSAID, SSRI, venlafaxine, clopidogrel, prasugrel, glycoprotein inhibitors (abciximab)
Anticoagulants - warfarin, heparins, heparinoids, DOACs, fibrinolytics
What are the drugs that cause thromboembolism?
Cytotoxics - bleomycin, cyclophosphamide, thalidomide, vinca alkaloids, tamoxifen
Epoietin Alfa, oestrogens, tranexamic acid
What are the drugs that cause bradycardia?
Beta blockers Amiodarone Digoxin Rate limiting CCBs Clonidine
What drugs cause first dose hypotension?
Alpha blockers
ACEi/ARB
Nitrates
Indoramin
What drugs cause hypotension?
Beta blockers
CCBs
ACEi/ARB
Alpha blockers
Alcohol, dopamine receptor agonists, nitrates, diuretics, sildenafil, gliflozins, antipsychotics
What are the drugs that cause antimuscarinic effects?
Antimuscarinics Atropine TCA Antihistamines Clozapine Antipsychotics
What are the drugs cause CNS depressant effects?
Alcohol Agomelatine Anaesthetics Antiepileptics Antihistamines Antipsychotics Baclofen Benzodiazepines Ketamine Melatonin Opioids Venlafaxine Z drugs
What are the drugs that cause peripheral neuropathy?
Amiodarone Cisplatin Disulfiram Phenytoin Isoniazid Metronidazole Vinka alkaloids
What are the drugs causing serotonin syndrome?
Triptans, bupropion, buspirone, TCA, MAOI, SSRI, MAOB inhibitors (selegiline), 5HT3 antagonist (ondansetron), amfetamines, St. John’s wort
What are the drugs that cause ototoxicity?
Aminoglycosides Cisplatin Glycopeptides (vancomycin) Loop diuretics Vinca alkaloids
What are the drugs that lower the seizure threshold?
Quinolones Mefloquine SSRI Antipsychotics Tramadol Theophylline Lithium Baclofen Amfetamines
What drugs cause oral ulcers?
ACEi NSAID Nicorandil Pancreatin Cytotoxic
What drugs cause oral candidiasis?
Corticosteroid inhalers
What drugs cause staining of teeth?
Chlorhexidine (brown)
Liquid iron (black)
Tetracyclines (yellow + grey)
What are the drugs that lower the seizure threshold?
Quinolones Mefloquine SSRI Antipsychotics Tramadol Theophylline Lithium Baclofen Amfetamines
What are the drugs that cause ototoxicity?
Aminoglycosides Cisplatin Glycopeptides (vancomycin) Loop diuretics Vinca alkaloids
What are the drugs causing serotonin syndrome?
Triptans, bupropion, buspirone, TCA, MAOI, SSRI, MAOB inhibitors (selegiline), 5HT3 antagonist (ondansetron), amfetamines, St. John’s wort
What are the drugs that cause peripheral neuropathy?
Amiodarone Cisplatin Disulfiram Phenytoin Isoniazid Metronidazole Vinka alkaloids
What are the drugs cause CNS depressant effects?
Alcohol Agomelatine Anaesthetics Antiepileptics Antihistamines Antipsychotics Baclofen Benzodiazepines Ketamine Melatonin Opioids Venlafaxine Z drugs
What are the drugs that cause antimuscarinic effects?
Antimuscarinics Atropine TCA Antihistamines Clozapine Antipsychotics
What drugs cause hypotension?
Beta blockers
CCBs
ACEi/ARB
Alpha blockers
Alcohol, dopamine receptor agonists, nitrates, diuretics, sildenafil, gliflozins, antipsychotics
What drugs cause first dose hypotension?
Alpha blockers
ACEi/ARB
Nitrates
Indoramin
What are the drugs that cause bradycardia?
Beta blockers Amiodarone Digoxin Rate limiting CCBs Clonidine
What are the drugs that cause thromboembolism?
Cytotoxics - bleomycin, cyclophosphamide, thalidomide, vinca alkaloids, tamoxifen
Epoietin Alfa, oestrogens, tranexamic acid
What are the drugs that increase the risk of bleeding?
Anti platelets - NSAID, SSRI, venlafaxine, clopidogrel, prasugrel, glycoprotein inhibitors (abciximab)
Anticoagulants - warfarin, heparins, heparinoids, DOACs, fibrinolytics
What are the drugs that cause hypokalaemia?
Loop/thiazide diuretics Corticosteroids Beta 2 agonist Theophylline Stimulant laxatives Amphotericin B
What are the predisposing factors for QT prolongation?
Increasing age Female Cardiac disease Bradycardia Electrolyte disturbances
What drugs cause QT prolongation?
Antipsychotics- pimozide, haloperidol, quetiapine
Antidepressants- citalopram/escitalopram, TCA, venlafaxine
Anti-arrhythmics - sotalol, amiodarone
CNS - methadone, lithium, triptans, apomorphine, ondansetron, domperidone, metoclopramide, quinine
Macrolides, hydroxychloroquine, chloroquine, quinolone, ketoconazole, itraconazole
What drugs cause contact sensitisation?
Methotrexate
Chlorpromazine
Cytotoxics
What are the drugs that cause photo sensitisation?
Antifungals - voriconazole
Tetracyclines- doxycycline, demeclocycline
Co-trimoxazole, quinolones (oxacins)
Hydroxychloroquine, chloroquine
Amiodarone PhenothiazineS Tacrolimus Topical NSAIDs Benzoyl peroxide Isotretinoin Vitamin A
What are the symptoms of myelosuppression?
Low blood count
Susceptible to infection
Anaemia
Thrombocytopenia
What drugs cause osteonecrosis of the jaw?
Bisphosphonates
What are the drugs that cause myelosuppression?
DMARDs - methotrexate, penicillamine, gold
Antiepileptics - carbamazepine, ethosuximide, lamotrigine, phenytoin
Antibiotics- linezolid, chloramphenicol, dapsone, co-trimoxazole, trimethoprim
Immunosuppressants- azathioprine, cytotoxics
Antifolates - phenytoin, methotrexate, trimethoprim
Others - aminosalicylates, carbimazole, clozapine, mirtazapine
What drugs cause taste disturbance?
ACEi Amiodarone Carbimazole Clarithromycin Lithium Metformin Metronidazole Zopiclone
What drugs cause dry mouth?
Antimuscarinics Antipsychotics Opioids Excessive diuretics Antihistamines Antidepressants
What drugs cause gingival hypertrophy?
Ciclosporin
Nifedipine
Phenytoin
What are the drugs that increase serum potassium?
ACEi/ARB Aldosterone antagonists Heparins NSAIDS Tacrolimus Triamterene Trimethoprim
What are the drugs that reduce serum potassium?
Aminophylline/theophylline Amphotericin B B2 agonists Corticosteroids Diuretics Stimulant laxatives
What are the drugs that cause hyponatraemia?
Carbamazepine
Diuretics
Antidepressants
