Antidiuretic Hormone Disorders Flashcards
What is diabetes insipidus?
Large amounts of dilute urine are produced which causes extreme thirst
What are the two types of diabetes insipidus?
Cranial
Nephrogenic
What is used to treat cranial diabetes insipidus?
Vasopressin or desmopressin
What is cranial diabetes insipidus?
The hypothalamus does not make enough ADH
What is used to treat nephrogenic diabetes insipidus?
Thiazide diuretics
What is nephrogenic diabetes insipidus?
The kidneys do not respond to ADH
What is desmopressin?
More potent analogue of vasopressin with a longer duration of action and no vasoconstrictor effects
What is desmopressin used for?
Diabetes insipidus
Nocturnal enuresis
What are the side effects of desmopressin?
Hyponatraemic convulsions
What is the syndrome of inappropriate anti diuretic hormone secretion?
Hyponatraemia caused by inappropriate secretion of ADH
What do you use to treat hyponatraemia if caused by inappropriate secretion of ADH when fluid restriction does not work?
Demeclocycline
Tolvaptan
Why do you need to avoid the rapid correction of hyponatraemia?
Causes osmotic demyelination of neurones
Serious CNS effects
