Sleep Disorders Flashcards
What are the symptoms of insomnia?
Difficulty initiating sleep
Difficulty maintaining sleep
Early morning waking
Poor sleep quality
What are the types of insomnia?
Transient
Short term
Chronic
What is transient insomnia?
Caused by environmental factors
Choose short acting
Give only one or two doses
What is short term insomnia?
Related to emotional or medical problem
Last a few weeks
Take intermittently and omit some doses
Give for no more than 3 weeks
What is chronic insomnia?
Common causes - psychiatric disorders, alcohol, drug abuse, pain
Treat underlying cause
What are the Z-drugs?
CD4 part 1
Zopiclone - taste disturbance
Zolpidem - GI disturbance
Zaleplon - shortest acting
Used in sleep onset insomnia
Elderly patients
Little hangover effect
How long do you use the z-drugs for insomnia?
Short term use
4 weeks max
2 weeks if zaleplon for severe insomnia that interferes with daily life
What are the long acting benzodiazepine sedatives that are used in insomnia?
Nitrazepam
Flurazepam
Diazepam - dental procedures
Sleep maintenance insomnia that causes daytime effects
Anxiolytic effect during the day - diazepam sing,e dose at night
Hangover effect
What are the shorter acting hypnotic benzodiazepines?
Temazepam Lorazepam Loprazolam Lormetazepam Oxazepam
Sleep onset insomnia
Elderly patients, hepatic impairment
Little hangover effect
How long do you use benzodiazepines for in insomnia?
Short term use 2-4 weeks for severe, disabling insomnia or causing patient extreme stress
Why should you avoid Z drugs/benzodiazepines in elderly?
Ataxia
Confusion
Causes falls and injury
What are the other hypnotics used in insomnia?
Clomethiazile
Chloral hydrate
Antihistamines
Melatonin
How do the z drugs work?
Act on benzodiazepine site of GABAa receptors to facilitate and enhance binding of GABA to GABAa receptors
What are the z drugs used for?
Short term use up to 4 weeks (2 weeks if zaleplon) for severe insomnia that interferes with daily life
What are the side effects of z-drugs?
Paradoxical effects
Daytime sleepiness
Avoid long term use tolerance develops in 3-14 days