Doença do Neurônio Motor - SF Flashcards

1
Q

Esclerose lateral amiotrofica - ELA - causas

A

Sao degenerativas

Mais comum é a ELA, mas existe variantes

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2
Q

Existe doença do neuronio motor hereditarias

A

Atrofia muscular espinhal (AME) , ELA familiar / Kennedy

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3
Q

Causas infecciosas de doença do neuronio motor

A

Poliomielite / HIV / West Nile

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4
Q

Causas paraneoplasicas

A

E outras podem ser causas de dç neuronio motor

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5
Q

Fatores de risco predisponentes para ELA

A

Fatores geneticos - mutacao de superoxige desmutase 1(gente SOD1), mutacao TARDBP, mutacao C90rf72, mutacao TBK1 // Fatores ambientais - exposicao a metais pesados (chumbo, ferro, selenio, cadmio, mercurio), expo a pesticidas, expo a campos eletromagneticos, IMC e estado nutricional

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6
Q

Clinica

A

Instalacao cronica e assimetrica
ELA pega 1 e 2 neuronios
AME so pega 2 neuronio

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7
Q

Lesao de primeiro neuronio motor

A

Lesao central - hipertonia elastica (espasticidade) + reflexos exaltados + babinski

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8
Q

Lesao de segundo neuronio motor

A

Reflexos hipoativos + atrofia/hipotonia + fasciculacoes

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9
Q

ELA - definicao

A

Doenças de ambos os neuronios / pega varios segmentos / rapida progressao / pega musculatura respiratoria e bulbar / diag - clinico + suporte ENMG / tto - riluzol, suporte

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10
Q

AME - definicao

A

Genetica recessiva, bebes ou criancas (hipotonicos), segundo neuronio motor, progressao variavel, pode ser devastadora, diag - genetico (SMN), revolucao da medicina moderna / tto - nursinesen / terapia genica

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