chapter 17 Skin infections (diana's verison) Flashcards
Bacterial infections
Hair follicle infections:
most commonly caused by staphylococcus aureus
most strains have several virulence factors
what are the several virulence factors in bacterial infections
coagulase
protein A
hyaluronidase and collagenase
leukocidin
beta toxin
this exoenzyme promotes fibrin clots
coagulase
what does coagulase mean
this exoenzyme promotes fibrin clots
binds to the Fc fragment of antibodies , inhibits opsonization
protein A
what does protein A mean
binds to Fc fragment of antibodies, inhibits opsonization
degrades hyaluronic acid and collagen
hyluronidase and collagenase
what does hyaluronidase and collagenase mean
degrades hyaluronic acid and collagen
kills leukocytes (especially nutrophils)
leukocidin
what does leukocidin mean
kills leukocytes (especially neutrophils)
destorys cells by poking holes in the membrane
beta toxin
what is beta toxin
destroys cells by poking holes in the membrane
clots blood (serves as a fort) , hide (immune system cannot find it)= it is protective
coagulase
most abundant connective tissue, collagenese
cutting your collagen
pokes holes in the membrane, it dies and everything is gonna leak out
beta toxin
true or false. bacterial infections some strains possess additional virulence factors.
true
this is an exotoxin that causes the separation of skin layers
exfoliatin
describe the characteristics for exfoliatin
an exotoxin that cases the seperation of skin layers
causes scalded skin syndrome in newborns
transmitted by direct or indirect contact
-an issue in hospital nurseries
prevented using hexachlorophene
what causes the toxic shock syndrome
toxic shock syndrome toxin
where does toxic shock syndrome form from?
staphylococcus
toxic shock syndrome toxin
causes toxin syndorme
results from a localized infection
toxin is released into the blood behaving as a superantigen
causes an extreme immune reaction
-fever, rash, vomitting., shock, organ failure, and ften death
an ex: would be tampon use
toxins are produced in foods that are stored at rom temperature
enterotoxins
this is commonly produced by streptococcus pyogenes can caused also be caused by staphylococcus aureus
impetigo
usually requires a wound to penetrate the outer layers of the skin examples are cuts bites, scratches
impetigo
causes inflammation of epidermis and results in thin walled blister (breaks and oozes plasma) allows bacteria to spread to other areas of the skin
impetigo
this is transmitted by direct or indirect contact and treated with antibiotics
impetigo
this is an opening in the skin that lets them through , it hardens since its dehydrated.
Impetigo
Infectious fluid, can spread to other people can be harmful to someone who is not healthy
bacterial infections (impetigo)
Bacterial Infections: Acne Vulgaris is also known as a what?
inflammatory acne
what is acne vulgaris known caused by?
this is caused by Propionibacterium acenes ( a member of the normal microbiota)
where does acne vulgaris grow?
grows anaerobically in hair follicles
- eats sebum
-oil secreted production of sebum can block the follicle
-bacterial overgrowth leads to inflammation
how is acne vulgaris treated?
it is treated with antibiotics
benzyol peroxide
accutance (isoretinoin)
-reduces sebum production
-many side effects such as birth defects and depression
bacterial infections:
lyme disease how is this caused ?
this is cuased by borrelia burgdorferi
what is the morphology of lyme disease
spirochette
this commonly infects deer and mice and, they serve as a reservoirs and transmitted to humans by ticks and serve as a vectors
lyme disease
what are the symptoms for lyme disease?
1.Has a characteristics bullseye rash at the bite site
-followed by fever,muscle pain, and headache
-can last for two weeks
2.occurs weeks to months after initial infection
-characterized by arthritis, facial paralysis, irregular rhythms
3.occurs months to years later
- characterized by chronic arthritis, neurological changes including memory and mood changes and sleep disturbances.
what is the treatment for lyme disease? and when are they given?
antibiotics,the first stage
Treatment of lyme disease:
Arthritis and neurological changes are most likely due to ________
autoimmunity
Will antibiotics still be effective in second or third stage of lyme disease?
no, it is no longer effective
Viral infections are still in the _____
skin
this spread virus back and forth and have the capacity by going in the respiratory droplet
varicella
what is a varicella?
chickenpox caused by the Varicella-Zoster Virus
human herpes virus 3
What is known as a highly contagious viral infection and transmitted by respiratory droplet?
varicella
what is varicella characteristics? as being a varicella
patients develop a characteristics rash
raised itchy lessions all over the body
what is the incubation period with varicella
incubation period varies from 10-21 days
when the virus is done- does not leave
sleep in one neuron (falls asleep) and. never wake up
but some can-people who are immunocompromise
varicella can lead into shingles
what is varicella treated with?
it is treated with an antiviral (acyclvoir)
what is also used as a herpes medication? descreases the replication of the virus, you just have less, but it is still there, and the severity of the infection is lower (can tolerate better)
acyclovir
how could you prevent varicella
attenuated whole agent vaccine administered as a part of the MMRV engine
True or false. Rubeola is spread a respiratory spread and easy spread and seen as contagious
true
this is also known as a measles virus
rubeola
what is rubeola incubation period?
incubation period lasts 10-12 days
what are the signs and symptoms for rubeola
cold like symptoms, koplik spots, and a macular rash
what could be the possible complications of rubeola
virla pneumonia, encephalitis,brain damage, SSPE
what are the treatments available for viral infections (rubeola)
no treatment available
what is the prevention for rubeola
attenuated vaccine administered as a aprt of the MMRV vaccine
Beofre vaccination measles caused _____ million deaths per year
2.6
true or false. Huamns are the only reservoir, eradication is possible .immunocompormise people does not need to get vaccinated, pregnant women etc.
true
True or false. Anytime a human is only reservoir, you do not have to minimize exposure or vaccinate all the animals
true
post-vaccination- _____ deaths occur per year
200,000 deaths
Viral infections : (Rubella)
german measles caused by _____ virus
rubella
this causes a milder disease than measles (faint pink rash)
rbella
true or false. Rubella cause serious complications if infection occurs during pregnancy
true
fetus can develop ___ rubella syndrome
congenital
birth defects in rubella include :
eye cataracts ,deafness, heart defects, mental retardation and still birth
what is the treatment for rubella
none , there is NONE
what could be a way of “ prevention “ for rubella
attenuated vaccine administered as a part of the MMRV regime
characteristics for rubella:
Viral Infections
German measles caused by Rubella virus
causes a milder diseases than measles
- faint like pink rash
may cause serious complications if infection occurs during pregnancy
fetus can develop congenital rubella syndrome
birth defects include: eye cataracts, deafness, heart defects, mental retardation, and still birth
no treatment is possible
prevention:
attenuated vaccine administered as a part of the MMRV regime
Viral infections : ( Warts ) is a skin to skin contact. True or false?
true
what can be caused by human papillomavirus.
warts
what is seen as a small tumours on the skin and mucous membranes
warts can be seen as these
Can warts be transmitted by direct or indirect contact
both
specific viral types infect different types of skin and membranes , and what are the examples.
cause different types of warts
ex) plantar warts, genital warts, dermal warts
true or false. Warts : only some viral strains are considered oncogenic, what are the examples
true.
cervical cancer, mouth cancer, and throat cancers
how do you remove warts ?
by removing virally infected cells
- freezing with liquid nitrogen
-salicylic acid (compound W)
-surgical removal
what is the prevention (can be given to boys and girls) for warts?
The HPV vaccine protects against 4 different viral strains 2 of which are most commonly found in cervical cancer cases
this virus gets shed if the person touch the surface (skin to skin): it is domino effects and highly contagious , can be direct or indirect
warts
most of them is not a big deal, but if its in the cervic can lead into cervic cancer
warts (HPV)
Fungal Infections:
Cutaneous mycoses
fungi grows on hair ,nails, and outer layers of the skin
- use keratin protein as a nutrient source
example : ringworm
ring shaped fungal rash
- often occurs in moist areas of the body (athlete’s foot, jock itch)
how is cutaneous mycoses tretaed?
it is treated with topical creams containing azoles on the skin
oral griseofulvin for hair and nail infections
you have to keep it localized as you can
you do not pop a pill, you spread it through a topical cream
it has circular pattern ( looped around ) right onto the skin surface
fungal infections (cutaneous mycoses)
Fungal Infections:
candidiasis
caused by the yeast candida albicans
- causes thrush and vaginitis
an opportunistic pathogen
- infects when the normal microbiota is eliminated secondary to antibiotic use
how is candidiasis treated?
it is treated with topical azoles or mouthwash containing nystatin
these will not be killed (antibiotics)- more space and more food and overgrow that way you have to treat it to restore balance
candidiasis