Blood Flashcards
What type of tissue is blood?
A fluid connective tissue
What percentage of body weight is blood?
8%
What is made up of cells and cell fragments in a liquid matrix?
Blood
What is a liquid matrix?
Plasma
What does cells, cell fragments, and plasma make up?
Blood
What is blood made of?
Cells, cell fragments, and plasma
What percent of the blood is plasma?
55%
What makes up 55% of the blood?
Plasma
What color is plasma?
Pale yellow
What part of the blood is pale yellow?
Plasma
What makes up 90% of plasma?
Water
What makes up 8% of plasma?
Proteins
What makes up plasma? (Percents)
90% water, 8% proteins, and 2% other stuff
What is made up of water, proteins, and other stuff?
Plasma
What makes up 45% of whole blood?
Erythrocytes
What do erythrocytes make up?
45% of whole blood
What are erythrocytes made up of?
Hematocrit
What does hematocrit make up?
Erythrocytes
What are the formed elements?
Erythrocytes and the buffy coat
What makes up less than one percent of whole blood?
The buffy coat
What does the buffy coat made of?
Platelets
What do platelets make up?
The buffy coat
What do white blood cells make up?
Platelets
What are platelets made of?
White blood cells
What are erythrocytes?
Red blood cells
What are red blood cells?
Erythrocytes
What type of cells don’t have a nucleus or really any organelles?
Red blood cells/ erythrocytes
What don’t red blood cells have? What does this mean?
A nucleus or really any organelles, which means they can’t divide
What transports oxygen from the lungs to tissues, and carbon dioxide from tissues to lungs?
Erythrocytes
What do erythrocytes do?
They transport oxygen from the lungs to tissues, and carbon dioxide from tissues to lungs
What shape are erythrocytes?
Disk shaped/ a donut without a hole
Why are erythrocytes shaped the way they are?
To increase the surface area of the cell and be foldable
How long do erythrocytes live?
100 to 120 days
What type of cells live 100-120 days?
Erythrocytes
What is the main component of erythrocytes?
Hemoglobin
What is hemoglobin the main component of?
Erythrocytes
What does hemoglobin do?
It transports oxygen
What transports oxygen?
Hemoglobin
What does each globin protein have?
4 chains that attach to a heme pigment
What has 4 chains that attach to a heme pigment?
Hemoglobin
How much iron does each heme have?
1 iron atom
What happens when hemoglobin is exposed to oxygen?
The oxygen binds to the iron
What does oxygen bind with in hemoglobin?
It binds with the iron
What is oxyhemoglobin?
A complex of hemoglobin and oxygen
What is a complex of hemoglobin and oxygen called?
Oxyhemoglobin
How many red blood cells are in the body?
20-30 trillion
How many red blood cells are there in each microliter of blood?
5 million
How many hemoglobin molecules are there in each erythrocyte?
250+ million
How much oxygen does each hemoglobin molecule carry?
4
How many oxygen are there in a red blood cell?
1.08 billion
How many red blood cells are made per second in the body?
2 million
Why does the body make so many red blood cells?
To balance out the red blood cell death rate
What makes up 60% of plasma proteins?
Albumin
What percentage of plasma proteins is made up of albumin?
60%
What percentage of plasma proteins is made up of globulins?
36%
What percentage of plasma proteins is made up of fibrogens?
4%
What makes up 36% of plasma proteins?
Globulins
What makes up 4% of plasma proteins?
Fibrinogens
What does albumin do?
It helps maintain the water balance/ osmotic pressure
What are the three plasma proteins?
Albumin, globulin, and fibrinogen
What are albumin, globulin, and fibrinogen?
Plasma proteins
What helps maintain the water balance and osmotic pressure?
Albumin
What are the antibodies of the plasma proteins?
Globulin
What transports molecules that bind to lipids, metal ions, and soluble vitamins?
Globulins
What do globulins do?
They transport molecules that bind to lipids, metal ions, and fat-soluble vitamins
What do globulins transport?
Lipids, metal ions, and fat-soluble vitamins
Why is fibrinogen important?
It’s a critical part of blood clot formation
What is a critical part in blood clot formation?
Fibrinogen
What is albumin?
A plasma protein
What is globulin?
A plasma protein
What is fibrinogen?
A plasma protein
What is the process of forming blood cells in red bone marrow?
Hematapoesis
What is hematapoesis?
The process of forming blood cells in red bone marrow
What does hematapoesis form?
Red blood cells, white blood cells, and platelets
What does erythropoesis do?
It maintains the balance between blood cell production and destruction
What maintains the balance between red blood cell creation and destruction?
Erythropoesis
How many red blood cells are made per day on average?
200 billion
What does erythropoietin do?
It decreases the number of red blood cells
What decreases the number of red blood cells?
Erythropoietin
What can erythropoietin cause?
An insufficient amount of hemoglobin per red blood cell (An iron deficiency)
What can cause iron deficiencies?
Erythropoietin
What can cause an insufficient amount of hemoglobin per red blood cell?
Erythropoietin
What is caused by an insufficient amount of hemoglobin per red blood cell?
An iron deficiency
What can be caused by an iron deficiency?
A decrease in oxygen availability
What does erythropoietin base its destruction of red blood cells on?
Not the number of red blood cells, but their capability
What does erythropoiesis need to happen?
Iron, amino acids, and B vitamins
What needs iron, amino acids, and B vitamins?
Erythropoesis
What happens during erythrocyte destruction?
The cells become brittle and aged
What can trigger erythrocyte destruction?
Fragments in small cappillieries, especially in the spleen
What can fragments in small capillaries cause?
Erythrocyte destruction
What destroys erythrocytes?
Macrophages
What happens during erythrocyte destruction?
Macrophages salvage and store the iron, and the heme is degraded into bilirubin
What do macrophages do?
They help in erythrocyte destruction
What happens to heme after erythrocyte destruction?
It’s degraded into bilirubin, transported to the liver, and secreted from the bile to the feces
What makes feces brown?
The heme from destroyed erythrocytes that’s turned into bilirubin
What are blood related disorders?
Anemia and polycythemia
What are leukocytes?
They make up less than 1% of blood volume
What shape are leukeocytes?
Spherical
What is diapedesis?
The movement out of capillaries
What is the movement out of capillaries called?
Diapedesis
What is positive chemotais?
The movement towards capillaries
What is the movement towards capillaries called?
Positive chemotais
How many leukeocytes are made a day?
10 billion
What do leukeocytes do?
They protect against invaders and eat dead cell debris
What protects against invaders and eats dead cell debris?
Leukeocytes
What is the rhyme to remember the percentages of the different leukocytes?
Never let mommies eat bananas
What are the types of granulocytes?
Neutrophils, eosinophils, and basophils
How long are neutrophils in the blood?
10-12 hours
What type of leukocyte is in the blood for 10-12 hours?
Neutrophils
Where do neutrophils go after they’re in the blood?
They move into other tissues and eat foreign substances
What makes up a large portion of pus?
Neutrophils
What do eosinophils do?
They release chemicals to reduce inflammation and destroy some worm parasites
What releases chemicals to reduce inflammation?
Eosinophils
What destroys some worm parasites?
Eosinophils
What do basophils do?
They release histamine, chemicals that promote inflammation, and heparin
What does heparin do?
It helps prevent blood clotting
What prevents blood clotting?
Heparin
What releases histamine?
Basophils
What releases chemicals that promote inflammation?
Basophils
What releases heparin?
Basophils
What are the types of agranular leukeocytes?
Monocytes and lymphocytes
What are the two subcategories of leukocytes?
Granulocytes and agranular
What are the largest white blood cells?
Monocytes
What are macrophages in tissues?
Monocytes
What do monocytes do?
They phagocytoze debris and bacteria and present destroyed substances to lymphocytes
What phagocytizes debris and bacteria?
Monocytes
What presents destroyed substances to lymphocytes?
Monocytes
What are lymphocytes?
The smallest white blood cells
What are the smallest white blood cells?
Lymphocytes
What do lymphocytes do?
They produce antibodies and chemicals that destroy microorganisms
What are lymphocytes involved in?
Allergies, graft rejections, and tumor control
What is involved in allergies, graft rejection, and tumor control?
Lymphocytes
What produces antibodies and chemicals that destroy microorganisms?
Lymphocytes
What are platelets?
Minute fragments
What do platelets form?
Platelet plugs and clot formation
What do platelet plugs do?
They fix holes in vessels