Antimicrobial choice - EQ

Question 1

What is the MoA of b-lactams?

Answer 1

MoA - interfere w cell wall
indication - gram +, anaerob
with aminog and FQs

Question 2

cehalosporins?

Answer 2

MoA - resistant to bacterial defense.

indication - older gen like gram +, younger like gram -

Question 3

aminoglycosides?

Answer 3

MoA - pumped into gram -, bind to 30s ribosome

indication - gram -, pseudomonas

Question 4

chloramfenicol

Answer 4

MoA - binds to 50s ribosome

indication - broad spec, eye drops

Question 5

pot. sulphonamides

Answer 5

MoA - inhibit folic acid, dec PABA
indication - broad spec.
NOT anaerobes
DONT give with detomidine = fatal dysrhythmia

Question 6

tetracyclines

Answer 6

MoA - 30s ribosome, inhib protein synth

indication - broad spec. also protozoa, mycoplasma and erlichia

Question 7

FQs

Answer 7

MoA - inhib DNA gyrase so DNA doesnt align
indication - broad spec.
NOT anaerobes.
excreted unchanged in urine

Question 8

Macrolides

Answer 8

MoA - bind to 50S to inhibit protein synth

indication - ONLY to be given to foals with rhodococcus with rifampin

Question 9

rifampin

Answer 9

MoA - inhib RNA polymerase, to decr synth
indication - rhodococcus, staph
stains everything red*

Question 10

metronidazole

Answer 10

MoA - taken up by anaerobes, breaks into free rads which damage DNA
indication - ANAEROBIC and giardia*