Antibodies! ⚔ Flashcards

1
Q

D.M. tipo 1

A

Anti-GAD (anti-glutamato descarboxilasa)
Anti-IA2 (anti-tirosin fosfatasa 2)
Anti-insulina
Anti-Proinsulina

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2
Q

Tiroiditis de Hashimoto

Tiroiditis Linfocítica CRÓNICA

A

Anti-TPO (anti-peroxidasa) es el +Especif.

Anti-Tg (anti-tiroglobulina)

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3
Q

Tiroiditis Linfocítica SUBAGUDA

A

Positivo a anticuerpos anti-TPO (anti- peroxidasa)
Negativo a anticuerpos anti-Tg (anti-tiroglobulina)

[En Hashimoto ambos están positivos]

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4
Q

Tiroiditis de DeQuervain

Tiroiditis GRANULOMATOSA subaguda

A

NO es autoinmune, es post-infecciosa (post-viral)
⬆️ VSG.
Ab-TPO y TgAb: Negativos.

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5
Q

Hepatitis autoinmone

A

Anti Músculo Liso

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6
Q

Cirrosis Biliar Primaria

A

Anti mitocondrial

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7
Q

Enfermedad de Graves

A

TSI (Ig estimuladora de tiroides) es el + Específico.

TBII (Ig inhibidora del receptor de tirotropina)

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8
Q

Esclerodermia / Esclerosis sistémica

A

Ac anti-scl 70

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9
Q

Polimiositis / Dermatomiositis

A

Anti JO1

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10
Q

CREST

A

Ac anti-centrómero

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11
Q

LES

A

ANAs (el más sensible)
Anti-dsDNA
Anti-Smith (el más específico)

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12
Q

Anti Histonas

A

*Lupus-like inducido por fármacos (dacarbazina, hidralazina, procainamida)
AR
ARJ

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13
Q

Enfermedad mixta del tejido conectivo

A

Ac anti-RNP (ribonucleoproteína)

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14
Q

Sjögren

A

Ac anti-SSA/(Ro)

y anti-SSB/(La)

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15
Q

Lupus Neonatal (con afección cardiaca).

A

Anti-Ro

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16
Q

Lupus Eritematoso CUTÁNEO Subagudo (LECS)

A

Anti-Ro (SSA) + anti-ANAs

17
Q

Miastenia Gravis

A

anti-MUSK

18
Q

Granulomatosis de Wegener

Sinónimo: Granulomatosis con Poliangeitis

A

c-ANCA dirigido contra la proteinasa 3.

19
Q

Churg-Strauss

Sinónimo: Angeitis con Granulomatosis alérgica

A

p-ANCA dirigoda contra MPO.

20
Q

Anemia perniciosa

A

Ac anti-factor intrínseco (el +específico)

Ac anti-céls. parietales (baja especificidad)

21
Q

Enfermedad celíaca

A
Anti transglutaminasa (IgA)
Anti gliadina (IgA e IgG)
Anti endomisio (IgA)
22
Q

CUCI

A

pANCA

23
Q

Crohn

A

ASCA

24
Q

Artritis Reumatoide8

A
Factor Reumatoide (IgM anti IgG)
Ac anti-Péptido Cíclico Citrulinado (100% VPP)
25
Q

Sx antifosfolípidos primario

A

Ac anticoagulante lúpico
Ac anticardiolipina
Ac anti B2 glucoproteína 1

26
Q

Sx. Good-Pasture

A

Ac. anti-membrana basal glomerular

27
Q

Poliarteritis Microangiopática (PAM)

A

p-ANCA contra MPO.

*No confundir PAM con PAN (Poliarteritis Nodosa)

28
Q

Anticuerpos contra desmogleína 3 (desmosomas).

A

Pénfigo VULGAR.

29
Q

Anticuerpos contra hemidesmosomas (BPAG12).

A

Pénfigo BULOSO.

30
Q

Colangitis Esclerosante Primaria

A

p- ANCA