ADH Flashcards

1
Q

SIADH

A

syndrome of inappropriate ADH

Abnormal production, or sustained secretion of ADH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is SIADH characterized by?

A

Fluid retention
Serum hypoosmolality
Hyponatremia
Concentrated urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the causes of SIADH?

A

malignant – small cell carcinoma of the lung
CNS disorders – head trauma, stroke, tumor
Drug therapy – morphine, SSRI, chemo
Hypothyroidism, infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

pathogenesis of SIADH

A

Increased ADH

Increased water reabsorption in renal tubules – increases permeability

Increased intravascular fluid volume

Dilutional, hyponatremia and decreased serum osmolality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

osmolality of SIADH

A

Serum osmolality is low, hyponatremia

Urine osmolality in specific gravity is high

Serum sodium is low

urine output is low

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

t/f weight gain is a part of SIADH

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

s/sx SIADH– hyponatremia

A

Dyspnea
Fatigue
Neuro – told sensation, confusion, lethargy, muscle twitch, convulsions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

s/sx SIADH – G.I.

A

Impaired taste
Anorexia
Vomiting
Cramps

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what occurs with severe hyponatremia?

A

Irreversible, Neuro damage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What value is considered severe hyponatremia?

A

<100-115

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

can a patient die from water intoxication?

A

Yes, hypotonic medium – swelling in brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

T/F pharmalogic Therapy is the first line of treatment for SIADH

A

False, directed at underlying cause

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

diabetes insipidus

A

Deficiency of ADH, or a decreased Reno response to ADH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is diabetes insipidus characterized by?

A

Excessive lots of water in urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

neurogenic DI

A

Central

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

cause of neurogenic DI

A

Hypothalamus/pituitary gland damage

17
Q

what other disorders are associated with neurogenic DI?

A

Stroke
Traumatic brain injury
Brain surgery
Cerebral infections

18
Q

t/f neurogenic DI has a sudden onset

A

True, usually permanent

19
Q

where does the nephrogenic DI originate?

A

Renal origin

20
Q

cause of nephrogenic DI

A

Loss of kidney function
Can be drug related

21
Q

what disorder is associated with nephrogenic DI?

A

CKD

22
Q

T/F nephrogenic DI does not have a slow onset

A

False, progressive

23
Q

Pathogenesis of DI

A

decreased ADH

Decreased water reabsorption in renal tubules

Decreased intravascular fluid volume

Increased serum osmolality, excessive urine output

24
Q

Serum osmolality of DI

A

high

25
Q

urine osmolality in specific gravity of DI

A

Low

26
Q

serum sodium of DI

A

High

27
Q

urine output of DI

A

High

28
Q

t/f weight loss is associated with DI

A

True

29
Q

s/sx DI

A

Polyuria, polydipsia
Dehydration

Severe:
Electrolyte imbalance
Hypovolemic shock

30
Q

DILUTE

A

Dry
I & O, daily weight
Low specific gravity
Urinate a lot
Treat vasopressin
rEhydrate