ADH Flashcards
SIADH
syndrome of inappropriate ADH
Abnormal production, or sustained secretion of ADH
what is SIADH characterized by?
Fluid retention
Serum hypoosmolality
Hyponatremia
Concentrated urine
What are the causes of SIADH?
malignant – small cell carcinoma of the lung
CNS disorders – head trauma, stroke, tumor
Drug therapy – morphine, SSRI, chemo
Hypothyroidism, infection
pathogenesis of SIADH
Increased ADH
Increased water reabsorption in renal tubules – increases permeability
Increased intravascular fluid volume
Dilutional, hyponatremia and decreased serum osmolality
osmolality of SIADH
Serum osmolality is low, hyponatremia
Urine osmolality in specific gravity is high
Serum sodium is low
urine output is low
t/f weight gain is a part of SIADH
True
s/sx SIADH– hyponatremia
Dyspnea
Fatigue
Neuro – told sensation, confusion, lethargy, muscle twitch, convulsions
s/sx SIADH – G.I.
Impaired taste
Anorexia
Vomiting
Cramps
what occurs with severe hyponatremia?
Irreversible, Neuro damage
What value is considered severe hyponatremia?
<100-115
can a patient die from water intoxication?
Yes, hypotonic medium – swelling in brain
T/F pharmalogic Therapy is the first line of treatment for SIADH
False, directed at underlying cause
diabetes insipidus
Deficiency of ADH, or a decreased Reno response to ADH
what is diabetes insipidus characterized by?
Excessive lots of water in urine
neurogenic DI
Central