8.3 Flashcards
define Pain
unpleasant sensory and emotional experience associated with actual or potential tissue damage
what is Congenital Pain Insensitivity?
cannot feel pain or feel less pain than normal due to a genetic cause
what is Aquired Pain Insensitivity?
like in Syringomyelia= degeneration of tissue around central cavity of the spinal cord
two types of Analgesia?
- major- opoid based
2. minor- non opoid based
types of pain?
- nociceptive (what we know and love)
- neuropathic (problem in the pain pathway)
- central (like thalamic pain)
A delta fibers project to which Lamina?
I
V
C fibers project to which Lamina?
II
which fibers interact and modulate pain?
A b fibers which project to Lamina IV
which pathways does the pain sensetion includes?
anterolateral
spinoreticular
spinomesencephalic
describe spinoreticular pathway
responsible for alertness
describe spinomesencephalic pathway
includes the periaqueductal gray matter
regulates transmission of pain to the spinal cord
what is the name for higher sensitivity to pain?
hyperalgesia= lower threshold for pain
what happens in primary hyperalgesia?
damaged cells release mediators that release mediators that cause increased sensitivity to pain
which substances are released in primary hyperalgesia?
- K+ ions (causes increased excitability of nociceptors)
- H+
- Bradyknin (bradyknin R in sensory terminals produce Ca++ signals)
- Prostaglandins (can be reduced by Aspirin)
what happens in secondary hyperalgesia?
near the damaged cells there is Hyperalgesia although the cells there are not harmed
