1.4 Flashcards
ion channels are:
- pore forming, transmemb. proteins
- passive
- selective
- gated
- fast
what are the general functions of ion channels?
- establish resting memb. potential
- shaping AP
- regulate cell volume
in what ways can we classify ion channels?
- based on ion charge
- based on gating mechanism
- ion type
give examples for different ion channels based on gating mechanism?
- voltagae gated
- second messenger gated
- ligand gated
- mechanosensitive
- heat/light sensitive
what are the 3 configurations of voltage gated Na+ channel?
1, closed but activatable
- open
- close but inactivatable
what are Inwardly-Rectifing K+ channels?
passes + current more easily into the cell than out of it
where can we find Inwardly-Rectifing K+ channels?
cardiac myocytes to slow membrane repolarization
which subunit in the VG Ca++ Channel forms the pore?
a1
functions of VG Ca++ Channel
- Ca++ sensitive K+ channel activation
- muscular contraction
- Hormone/NT release
- Gene expression regulation
L-Type VG Ca++ Channel location
skeletal m
smooth m
ventricular myocytes
L-Type VG Ca++ Channel functions
cardiac AP plateau
smooth+skeletal m contraction
T-Type VG Ca++ Channel location
SA node
T-Type VG Ca++ Channel functions
pace maker activity
N-Type VG Ca++ Channel location
brain and PNS
N-Type VG Ca++ Channel functions
synaptic NT vesicle release
