Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

SN Physiology Final > 6.3 > Flashcards

6.3 Flashcards

1
Q

thrombin activation occurs through?

A

intrinsic and extrinsic pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Intrinsic pathway will happen after

A

endothelial damafe and collagen exposure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Describe Intrinsic pathway players

A 
XII
XI
IX
VIII
calcium
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Extrinsic pathway will happen after

A

tissue trauma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Describe Extrinsic pathway players

A

TF
VII
calcium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

where can we find TF?

A

on cells that are not present in contact with blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Describe Extrinsic pathway mechanism

A

VII become in contact with TF -> VIIa

togather they convert X -> Xa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

describe the prothrombinase complex

A

Xa forms a complex with Va

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

job of the prothrombinase complex

A

prothrombin -> thrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

how does the Intrinsic pathway activate?

A

XII -> XIIa by negative charges (collagen)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Describe Intrinsic pathway mechanism

A

XIIa -> XI -> XIa -> IX -> IXa -> X -> Xa with VIIIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Intrinsic tenase complex?

A

IXa with VIIIa acts on X

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what else can activate the intrinsic pathway?

A

extrinsic tenase complex

at factor IX

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what else activates factor XI?

A

Thrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

describe Fibrin formation

A

thrombin converts fibrinogen dimers into fibrin monomers -> fibrin monomers polymerize to form fibrin fibers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

activation of XIII?

A

by thrombin

17
Q

what is XIII?

A

Transglutaminase

18
Q

what do Plasminogen binds?

A

Lysine residues on the Fibrin mesh

19
Q

what will happen after bonding of Plasminogen to Fibrin?

A

tPA and uPA factors will activate Plasminogen to Plasmin which will cut Fibrin to smaller pieces

20
Q

what will inhibit plasminogen activation by tPA?

A

PAI-1

21
Q

what is the primary inhibitor of Plasmin?

A

a2-plasmin inhibitor

22
Q

what will TAFI do?

A

will remove Lysine residues from Fibrin

23
Q

Physiological Anti-coagulants

A

Activated protein C
Antithrombin
TFPI

24
Q

important functions of Thrombin?

A 
fibrinogen -> fibrin
XIII -> XIIIa
platelets activation
TAFI activation
activstes V, VIII, XI
activated protein C with Thrombomodulin
25
Q

factors produced by endothelial cells

A 
PGI2
NOvWf
Thrombomodulin
tPA
PAI-1

SN Physiology Final (59 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions