6.3 Flashcards
thrombin activation occurs through?
intrinsic and extrinsic pathway
Intrinsic pathway will happen after
endothelial damafe and collagen exposure
Describe Intrinsic pathway players
XII XI IX VIII calcium
Extrinsic pathway will happen after
tissue trauma
Describe Extrinsic pathway players
TF
VII
calcium
where can we find TF?
on cells that are not present in contact with blood
Describe Extrinsic pathway mechanism
VII become in contact with TF -> VIIa
togather they convert X -> Xa
describe the prothrombinase complex
Xa forms a complex with Va
job of the prothrombinase complex
prothrombin -> thrombin
how does the Intrinsic pathway activate?
XII -> XIIa by negative charges (collagen)
Describe Intrinsic pathway mechanism
XIIa -> XI -> XIa -> IX -> IXa -> X -> Xa with VIIIa
Intrinsic tenase complex?
IXa with VIIIa acts on X
what else can activate the intrinsic pathway?
extrinsic tenase complex
at factor IX
what else activates factor XI?
Thrombin
describe Fibrin formation
thrombin converts fibrinogen dimers into fibrin monomers -> fibrin monomers polymerize to form fibrin fibers
activation of XIII?
by thrombin
what is XIII?
Transglutaminase
what do Plasminogen binds?
Lysine residues on the Fibrin mesh
what will happen after bonding of Plasminogen to Fibrin?
tPA and uPA factors will activate Plasminogen to Plasmin which will cut Fibrin to smaller pieces
what will inhibit plasminogen activation by tPA?
PAI-1
what is the primary inhibitor of Plasmin?
a2-plasmin inhibitor
what will TAFI do?
will remove Lysine residues from Fibrin
Physiological Anti-coagulants
Activated protein C
Antithrombin
TFPI
important functions of Thrombin?
fibrinogen -> fibrin XIII -> XIIIa platelets activation TAFI activation activstes V, VIII, XI activated protein C with Thrombomodulin
factors produced by endothelial cells
PGI2 NOvWf Thrombomodulin tPA PAI-1
