1.7

Question 1

Define what a synaps is

Answer 1

a site where info. is transmitted from one cell to another, either electrically or chemically

Question 2

what is electrical synaps?

Answer 2

allows current to flow from one excitable cell to another via low resistance gap junction

Question 3

what are the characterisctics of electrical synaps?

Answer 3

• very fast
• cardiac muscle and single unit smooth muscle
• bidirectional
• no delay

Question 4

Gap btw pre and post synaptic cells is called

Answer 4

synaptic cleft

Question 5

what causes the NT to release?

Answer 5

AP in the presynaptic cell causes Ca++ channels to open -> Ca++ signal -> exocytosis of the NT

Question 6

change in the membrane potential can be

Answer 6

EPSP

IPSP

Question 7

what happens to the NT after it finished his job?

Answer 7

enztmatically degraded
diffused away
reuptake

Question 8

EPSP mV values

Answer 8

0.1-5 mV depolarization for milisec

Question 9

Glu R

Answer 9

Ionotropic

Metabotropic

Question 10

Ionotropic Glu R

Answer 10

AMPA (Na+)

NMDA (Na+ and Ca++ more active upon depolarization)

Question 11

GABA R types

Answer 11

GABA A= ligand gated Cl- channel

GABA B= Gi GPCR (opening of K+ channels)

Question 12

Define Spatial summation

Answer 12

several different pre-synaptic neurons firing at the same time) at different synaps on the neuron

Question 13

Define Temporal summation

Answer 13

same pre synaptic neuron fire multiple time in close succession

Question 14

ACh

Role in the body

Answer 14

• used in the spinal cord neurons to control muscles
• used in many neurons in the brain to regulate memory
• *mostly excitatory

Question 15

Glu

Role in the body

Answer 15

Most common excitatory NT in the brain

Question 16

Gly

Role in the body

Answer 16

used mainly in spinal cord neurons

**Inhibitory

Question 17

NE

Role in the body

Answer 17

NT and a hormone

• in the peripheral NS, its part of the fight or flihgt
• in the brain, regulated normal brain processes

Question 18

Describe the Axonal transport of the Synaptic Vesicle

Answer 18

Along microtubules, with motor proteins (kinesin, Dinein)

Question 19

NT is taken up into the synaptic vesicle by

Answer 19

NT-Proton antiporter
**remember that protons are brought into the vesicle by
V-Type H+ pump (using ATP)