5.4 Flashcards
exocrine pancreas secretes how many fluid?
1 liter / day
exocrine pancreas is __% of pancreas
90%
enzymes are secreted by
acinar cells
aqueous component is secreted by
centroacinar cells
digestive enzymes secreted by the pancreas
Amylase Trypsinogen Chymotrypsinogen Carboxipeptidase Elastase Lipase-Colipase PLP A2 Cholesterol ester Hydrolase
What substances regulate the secretion of pancreatic cells?
VIP Secretin GRP ACh CCK
Pancreatic juice contains
Na+
Cl-
K+
HCO3-
and also enzymes
At high pancreatic flow, the conc of HCO3- is very
High
what stimulates the secretion of pancreatic juice in the intestinal phase?
acidic duodenum (pH<4.5) AA, FA, Ca++ Distension of the duodenum
which mediator will work when acidic duodenum (pH<4.5)
Secretin will stimulate duct cells
which mediator will work when AA, FA, Ca++ are felt
CCK stimulates vagovagal reflex stimulate duct cells
which mediator will work when Distension of the duodenum is felt?
Enteropancreatic reflexes stimulate duct cells
what happens when there is a desrease in the duodenal pH?
S cells secrete Secretin -> Secretin stimulates Ductular Bicarbonate secretion -> will make pH go up
Bile is a mixture of
Hepatic and Gallbladder bile
composition of human hepatic duct bile
water- 97% bile salts- 0.7% bile pigments- 0.2% cholesterol- 0.06% inorganic salts- 0.7% FA- 0.15% phosphatidylcholine- 0.2% Fat- 0.1%
