1.10 Flashcards
main function of the autonomic NS
maintain constant internal enviromnent= homeostasis
preganglionic parapympathetic neuron cell bodies are located in
cranial
sacral
parasymp cranial nerve nuclei include
accessory occulomotor
sup and inf salivatory
dorsal vagal
nucleus ambigus
which pre ganglionic fibers are longer?
symp/parasymp
parasymp
preggl parasymp usually send ACh to what R?
nicotinic
why M2 R is unique?
activates Gi that leads to an alpha subunit binding directly to K+ ch in the heart (causing hyperpolarization)
what is the difference btw chronotropy and dromotropt?
chronotropy= related to HR dromotropy= related to conductance speed
right vagus nerve effect on the heart
effect SA node, negative chronotropy
left vagus nerve effect on the heart
effect AV node, negative dromotropy
longer PQ interval
sympathetic nervous transmission has what origin in the body?
thoraco-lumbar
preggl fibers come from the thoracic and lumbar spinal cord
in case of sweat glands, ______ NS uses ____to activate _______ receptors
sympathetic
ACh
muscarinic R
where can we find a1 receptors?
vascular SMC of skin. muscle, splanchnic region
spinchters of GI and bladder
radial muscle of the iris
what will DAG do?
activates PKC
Gq will activate
Phospholipase C
which is the dominants NT in a1?
N/NE
NE
where can we find B1 R?
prominent in the heart (SA, AV nodes, ventricular muscles)
salivary glands
adipose tissue
kidney (promote Renin secretion)
where can we find B2 R?
vascular smooth muscle cells within the heart and in the bronchiols
bronchioles SMC
Functions of B2 R?
relaxation and dilation of SMC to increase blood flow
B3 R are for
lipolysis in adipose tissue
Aggonist affinity of a1 R
NE>EPI
Aggonist affinity of a2 R
NE>EPI
Aggonist affinity of B1 R
EPI=NE
Aggonist affinity of B2 R
EPI»NE
Aggonist affinity of B3 R
NE>EPI
