[47] Key Concepts and Definitions

Question 1

What are Antifibrotic CAR T Cells?

Answer 1

Cells developed by delivering modified mRNA in lipid nanoparticles targeted to T cells.

Question 2

CAR - Initials

Answer 2

Chimeric Antigen Receptor

Question 3

T Cells - Full Form

Answer 3

T lymphocytes

Question 4

What is Efficient mRNA Delivery in the context of this study?

Answer 4

Process that ensures modified mRNA encoding the CAR is effectively transferred to T lymphocytes.

Question 5

What is Transient Efficacy of CAR T Cells?

Answer 5

CAR T cells are temporary but effective.

Question 6

mRNA - Initials

Answer 6

Messenger RNA

Question 7

What is Trogocytosis?

Answer 7

Intercellular transfer of membrane patches, leading to antigen retention and spleen accumulation.

Question 8

LNP - Initials

Answer 8

Lipid Nanoparticles

Question 9

What is Therapeutic Impact in this study?

Answer 9

Reduction of fibrosis and restoration of cardiac function post-injury.

Question 10

What is Cardiac Fibrosis?

Answer 10

Thickening and stiffening of heart tissues, affecting heart function.

Question 11

CD5-targeted LNPs

Answer 11

Lipid nanoparticles designed to target CD5, a protein on T cells.

Question 12

FAP - Initials

Answer 12

Fibroblast Activation Protein

Question 13

AngII/PE - Initials

Answer 13

Angiotensin II and Phenylephrine

Question 14

What is Fibroblast Activation Protein (FAP)?

Answer 14

Marker for activated fibroblasts; targeted by CAR in this study.