[39] Key Findings and Significance Flashcards
1
Q
How many single cardiac nuclei were sequenced?
A
287,269
2
Q
How many major cell types were identified?
A
Nine major cell types
3
Q
How many subclusters within the human heart were discovered?
A
20 subclusters
4
Q
Name three types of identified cellular subclasses.
A
- Resident macrophage groups
- Endothelial subtypes
- Fibroblast subsets
5
Q
What was unique about the transcriptional programs of cardiomyocytes?
A
Diversity by cardiac chamber and sex
6
Q
How did genetic data intersect with the findings?
A
Enrichment for cell subtypes’ roles in cardiac traits and diseases
7
Q
What advantages have recent developments in single-cell sequencing provided?
A
In-depth view of cell subtype diversity in health and disease
