[36] Clonal Haematopoiesis & Therapeutic Targets

Question 1

CHIP - Initials

Answer 1

Clonal Haematopoiesis of Indeterminate Potential

Question 2

DNMT3A - Initials

Answer 2

DNA Methyltransferase 3 Alpha

Question 3

What do immune cells with mutations in the CHIP-driver gene DNMT3A express?

Answer 3

High levels of genes encoding inflammasome complex, pro-inflammatory cytokines, and Resistin.

Question 4

What does the study suggest for potential interventions targeting CHIP mutation status?

Answer 4

Interventions targeting interleukin-1β, interleukin-6, inflammasome activation, or T-cell co-stimulation could reduce cardiovascular risk.