[45] Insights and Future Work

Question 1

Can targeting activated cardiac fibroblasts using engineered T cells be used in humans?

Answer 1

Potentially, but more work is needed for safety and efficacy confirmation.

Question 2

What should future work focus on?

Answer 2

• Minimizing safety risks
• Identifying optimal CAR constructs
• Investigating other potential target antigens

Question 3

What are the implications of the study?

Answer 3

Engineered T cell therapy can extend beyond oncology to target cardiac fibrosis.

Question 4

What should future work include to ensure safety?

Answer 4

• Determine optimal target for immunotherapy
• Design CAR constructs with high efficacy and safe profiles
• Incorporate “kill-switches” in engineered T cells