[42] Targeting Cardiac Fibrosis with Engineered T cells

Question 1

What is Cardiac Fibrosis?

Answer 1

Overgrowth, hardening, or scarring of cardiac tissue due to excess deposition of extracellular matrix.

Question 2

What role do Cardiac Fibroblasts (CFs) play in Cardiac Fibrosis?

Answer 2

Remodel myocardium through extracellular matrix deposition, leading to tissue stiffness and reduced compliance.

Question 3

What is Redirected T-cell Immunotherapy?

Answer 3

A study that uses modified T cells to target and eliminate pathological cardiac fibrosis.

Question 4

What is Fibroblast Activation Protein (FAP)?

Answer 4

An endogenous target on CFs identified for its role in cardiac fibrosis.

Question 5

Define Chimeric Antigen Receptor (CAR) T cells.

Answer 5

Engineered T cells reprogrammed to express a CAR against FAP.