[33] Transcriptomic Responses in Cardiac Conditions

Question 1

What does scRNA-seq offer for deconvolution of transcriptomic responses?

Answer 1

Detailed insights into cellular responses at cell-type level in heart conditions.

Question 2

What cell types were identified to respond differently to cardiac injury?

Answer 2

• Cardiomyocytes
• Fibroblasts
• Endothelial cells
• Immune cells

Question 3

snRNA-seq - Initials

Answer 3

Single-nuclei RNA-sequencing

Question 4

lncRNAs - Initials

Answer 4

Long non-coding RNAs

Question 5

What do cardiomyocytes express in response to cardiac injury?

Answer 5

lncRNAs involved in re-expression of fetal genes.

Question 6

How do fibroblasts respond to cardiac injury or aging?

Answer 6

Heterogenic response

Question 7

What changes do endothelial cells show following myocardial infarction?

Answer 7

Metabolic adaptations with transiently enhanced mesenchymal gene signatures.

Question 8

What immune cells exhibit distinct alterations post-myocardial infarction?

Answer 8

• Macrophages
• Neutrophils
• T-cells

Question 9

What novel findings were shown about cardiomyocyte response?

Answer 9

Identified distinct subpopulations, key regulatory networks, and lncRNAs like Gas5 and Sghrt.

Question 10

DCM - Initials

Answer 10

Dilated Cardiomyopathy

Question 11

What do distinct age-based profiles in DCM patients suggest?

Answer 11

Different therapeutic strategies might be beneficial for regenerative or antifibrotic treatments.