[14] AF Mechanisms and Treatment Flashcards
1
Q
What are the two critical components in the genesis of AF?
A
- Trigger
- Vulnerable Substrate
2
Q
What is the trigger often caused by in AF?
A
Calcium (Ca2+)-handling abnormalities.
3
Q
What is a vulnerable substrate characterized by in AF?
A
- Short effective refractory period (ERP)
- Slow, heterogeneous conduction velocity
4
Q
ERP - Initials
A
Effective Refractory Period
5
Q
What is the main AF-maintaining mechanism?
A
Re-Entry Phenomenon
6
Q
What are the implications for AF treatment?
A
Need for customized therapies targeting specific phenotypes.
