[18] Molecular Basis of Obesity and AF Flashcards

1
Q

What is HFD?

A

High-Fat Diet, used in animal models to study obesity-driven atrial remodeling

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2
Q

Structural and functional remodeling due to obesity?

A
  • Enlargement and fibrosis
  • Changes in ion currents
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3
Q

What is NLRP3-Inflammasome?

A

A complex involved in immune responses, linked to obesity-driven AF

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4
Q

Impact of NLRP3-Inflammasome in obesity-related AF?

A
  • Abnormal Ca2+ release
  • Upregulation of K+-currents
  • Reduced atrial AP duration
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