[18] Molecular Basis of Obesity and AF Flashcards
1
Q
What is HFD?
A
High-Fat Diet, used in animal models to study obesity-driven atrial remodeling
2
Q
Structural and functional remodeling due to obesity?
A
- Enlargement and fibrosis
- Changes in ion currents
3
Q
What is NLRP3-Inflammasome?
A
A complex involved in immune responses, linked to obesity-driven AF
4
Q
Impact of NLRP3-Inflammasome in obesity-related AF?
A
- Abnormal Ca2+ release
- Upregulation of K+-currents
- Reduced atrial AP duration