[06] Key Findings Flashcards
1
Q
What percentage of obese mice developed AF in the study?
A
100%
2
Q
What ion channel alterations were observed in obese mice?
A
- Reduced Nav1.5 expression
- Alterations in potassium channel expression (Kv1.5)
3
Q
What stress markers were elevated in obese mice?
A
- F2-isoprostanes
- NOX2
- PKC-α/δ
4
Q
What structural changes were found in obese mice?
A
Increased atrial fibrosis
5
Q
Can the changes be reversed?
A
Yes, using mitochondrial antioxidant therapy.
