[43] Findings and Conclusions

Question 1

What cells can be effectively targeted and ablated using antigen-specific CD8+ T cells?

Answer 1

CFs expressing a xenogeneic antigen.

Question 2

What impact do T cells with a CAR against FAP have on cardiac fibrosis in mice?

Answer 2

Significant reduction and restoration of cardiac function post-injury.

Question 3

What happens when activated cardiac fibroblasts are targeted by engineered T cells in mice?

Answer 3

Reduction in cardiac fibrosis.

Question 4

What is FAP’s relevance in targeting pathological cardiac fibroblasts?

Answer 4

It’s upregulated in hypertrophic or dilated cardiomyopathies.

Question 5

What safety profile did FAP CAR T cells show in mice?

Answer 5

Did not increase cytokine levels or cause cardiotoxicity.