15 November Flashcards
What are some long term effects of nitrofurantoin?
Pulmonary Fibrosis
Can accumulate in renal disease
What EGFR should nitrofurantoin be stopped in?
EGFR <45
What monitoring is required for DOACS?
U&Es- creatinine clearance
Once every 3-12months
Which anti-depressant is highest risk of withdrawal?
Venlafaxine and Paroxetine
Requires slower tapering than other anti-depressants
What are signs of Clozapine toxicity?
Hyperthermia
Drowsiness
Confusion
Hypersalivation
Seizures
What monitoring is required for Clozapine?
FBC weekly during initiation and monthly once established
Due to risk of agranulocytosis
What anti-epileptic medication should stopped in girls of reproductive age?
Sodium valproate
If cannot be switched then will need highly effective contraception and counselling of risk of pregnancy
What are some side effects of Carbamazepine?
Leucopenia
Agranulocytosis
thrombocytopenia
What are some side effects of melatonin?
Odd Dreams
Effect of behaviour
Arthralgia
Headaches
What cautions should be taken when norethisterone contraceptive is changed to COCP?
7 days of condom
Not required if switching from desogesterol
What is a side effect of clarithromycin?
Prolong QT intervalt
What is the starting dose of mirtazapine?
15mg
Started low due to side effects of drowsinessW
What contraception is contraindicated in hepatocellular carcinoma?
COCP
Which vaccine is contraindicated following anaphylactic egg allergy?
Yellow fever
What are side effects of anti-malarial Mefloquine?
Abnormal Dreams
Insomnia
Anxiety
Depression
Suicidal ideation
Contraindicated in epilepsy
