[04] Protein Structure and Function Flashcards

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1
Q

What is a protein?

A

A macromolecule composed of amino acids linked by peptide bonds

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2
Q

What are the building blocks of proteins?

A

Amino acids

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3
Q

What forms a peptide bond?

A

The carboxyl group of one amino acid and the amino group of another

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4
Q

What are the four levels of protein structure?

A
  • Primary
  • Secondary
  • Tertiary
  • Quaternary
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5
Q

What is the primary structure of a protein?

A

The sequence of amino acids in a protein

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6
Q

What is the secondary structure of a protein?

A

The local folding pattern of the protein backbone, such as alpha-helices and beta-sheets

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7
Q

What is the tertiary structure of a protein?

A

The overall three-dimensional shape of a protein

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8
Q

What is the quaternary structure of a protein?

A

The assembly of multiple polypeptide chains into a functional protein complex

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9
Q

What are the roles of proteins in the body?

A
  • Enzymes
  • Structural proteins
  • Transport protein
  • Immunoproteins
  • Hormones
  • Storage proteins
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10
Q

How is protein structure related to its function?

A

The specific shape of a protein determines its function and interaction with other molecules

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11
Q

What is protein denaturation?

A

The process where a protein loses its native structure due to changes in temperature, pH, or chemical environment

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12
Q

What is a protein domain?

A

A segment of a protein that can fold independently into a compact, stable structure

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13
Q

What are globular and fibrous proteins?

A
  • Globular proteins → proteins that are generally water-soluble and spherical in shape
  • Fibrous proteins → proteins that are generally insoluble and have a structural role
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14
Q

What is an enzyme?

A

A protein that acts as a biological catalyst to accelerate chemical reactions

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15
Q

What is the active site of an enzyme?

A

The region of an enzyme where substrate molecules bind and undergo a chemical reaction

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16
Q

What are cofactors and coenzymes?

A
  • Cofactors → non-protein chemical compounds required for an enzyme’s activity
  • Coenzymes → organic molecules that assist enzymes during the catalysis of reactions
17
Q

What is an allosteric site?

A

A region in an enzyme other than the active site, where the binding of a molecule can change the function of the enzyme

18
Q

What is protein folding?

A

The process by which a protein structure assumes its functional shape or conformation

19
Q

What is a chaperone protein?

A

A protein that assists in the folding of other proteins

20
Q

What is a prion?

A

A misfolded protein that can trigger normal proteins to fold abnormally

21
Q

Give an example of a cofactor.

A

Iron (Fe) in hemoglobin

22
Q

Give an example of a coenzyme.

A

Vitamin B12 in methionine synthase