XI Chap 10 Cell Cycle & Division Flashcards
Growth and reproduction are characteristics of ALL living cells. T or F?
True
All cells reproduce by diving into 2. T or F?
True
During cell division, each parental cell gives rise to __________
two daughter cells
During cell division, ________ and ________ also take place
DNA replication, cell growth
Prokaryotes do not produce ________ and ______ during cell division
chromosomes, spindle fibres
There is no mitosis or phases of division in prokaryotes. T or F?
True
What is amitosis?
Cell division in prokaryotes / bacteria
Prokaryotes and Protista divide for _________ and ____________
growth, reproduction
Multicellular organisms divide for ____________, ____________, ____________ and ____________
growth, repair, replacement and maintaining nucleocytoplasmic ratio
What is cell cycle?
sequence of events
cell duplicates its genome
synthesises other cell constituents
divides into 2 daughter cells
Cell growth in terms of cytoplasmic increase is a discontinuous process broken down into distinct stages. T or F?
False, cytoplasmic increase is a continuous process
Cell growth only takes place in G1. T or F?
False, continuous but most in G1
DNA synthesis is a continuous process in cell cycle. T or F?
False, occurs only in one specific stage
Replicated chromosomes are distributed to daughter cells by a _______ _______ series of events under _______ control
complex, coordinated, genetic
A typical __________ cell cycle is demonstrated by human cells in culture
eukaryotic cell cyle
Human cells in culture divide once in approximately every _______
24 hours
Yeast divides in ___________
90 minutes
E. Coli divides once every ___________
20 minutes
2 basic phases of cell cycle:
Interphase
M Phase
All the phases of cell cycle
Gap 1, Synthesis, Gap 2, Prophase, Metaphase, Anaphase, Telophase, Cytokinesis
___________ phase represents when the actual cell division or mitosis occurs
M phase
___________ phase represents the phase between 2 successive M phases
Interphase
In 24 duration of human cell cycle, M-phase lasts only about _______
an hour
Interphase lasts for more than _____% of the cell cycle
95
In human cell in culture, time of each phase? M, G1, S, G2
M - 1 hour
G1 - 8-12 hours
S - 6-8 hours
G2 - 3-4 hours
DNA is in the form of _________ in each of the phases: M, G1, S, G2
M - chromosome
G1, S, G2 - chromatid
Cell cycle is regulated by ________ which are dependent on _________. Hence the regulators are called: __________
kinase (proteins)
cyclin (proteins)
CdK2 - cyclin-dependent kinase
M Phase starts with ________ and ends with ___________
nuclear division & separation of daughter chromosomes (karyokinesis);
division of cytoplasm (cytokinesis)
Interphase is aka _________ as cell is preparing for division
resting phase
Cell growth and DNA replication happen during the Interphase. T or F?
True
What are the 3 phases of interphase?
G1 (Gap 1), Synthesis and G2 (Gap 2)
What happens in G1 phase? (4)
Maximum cell/cytoplasmic growth
RNA, nucleotides, proteins, amino acids, ATPs are produced
max. cell organelles duplicated
DNA damage repair
What happens in S phase?
DNA replication in nucleus
histone synthesis and centriole duplication in cytoplasm
What happens in G2 phase? (4)
tubulin proteins synthesized (RNA and protein syn continues)
semi-autonomous organelles duplicate (mitochondria, chloroplast)
Golgi body duplicated
growth occurs but not much
_____ is the longest phase of interphase
_____ is the longest phase of cell cycle
G1, G1
_____ phase is shorter in frequently dividing cells (e.g. embryonic cells)
G1
What is the major checkpoint in cell cycle? What is it regulated by?
G1 —> S
regulated by G1 cyclin and CdK2
What is the minor checkpoint in cell cycle? What is it regulated by?
G2 —-> M
regulated by M cyclin and CdK2
_______ is pre-mitotic and post-synthetic
G2
_______ is post-mitotic and pre-synthetic
G1
________ phase is the interval between mitosis and initiation of replication
G1 phase
During _______ phase cell is metabolically active but doesn’t replicate DNA
G1
____chromatin replicate first and then ____chromatin
Euchromatin, heterochromatic
Amount of DNA per cell and number of chromosomes double during S phase. T or F?
False, amount of DNA (chromatid) doubles, but chromosome number is the same
Haploid cell becomes diploid after S phase of cell division. T or F?
False, number of chromosomes remains the same
In plant cells, during S phase, DNA replication begins in nucleus and centriole duplicates in the cytoplasm. T or F?
False, centriole only present in animal cells
Why is time for G1 phase so variable?
Because it is the only phase that depends on external factor (e.g. nutrients)
__________ skips G1 and G2 phase
Zygote in cleavage division (size doesn’t increase that much)
Heart cells and many others divide only occasionally, e.g. due to injury or cell death. T or F?
Heart cells and neurons do not divide ever, rest is accurate
Cells that do not divide further exit _____ phase to enter an inactive stage called _________
G1 phase, quiescent stage (G0)
Cells in G0 stage remain ________ but no longer proliferate unless called to do so.
metabolically active
Neurons remain in permanent _____ phase and do not enter ____ phase ever as they do not possess a ______
G1, S, centriole
From G1 phase, if cell goes into G0 phase its due to non-availability of _______ and ______
mitogen and energy-rich compounds
Once cell enters S phase it has to divide. T or F?
True
If a cell differentiates after G1 phase, its role becomes permanently fixed until natural death of cell. T or F?
True
Examples of cells that are constantly replaced by mitosis. (4)
Upper layer of epidermis,
cells of lining of gut,
blood cells,
cheek cells
In animals, mitotic cell division is only seen in ___________ cells
diploid somatic cells
Exceptionally, in some lower plants and social insects, ___________ cells divide by mitosis. Example?
haploid;
male honey bees
Plants show mitotic divisions in both haploid and diploid cells. T or F?
True
Tubulin protein is made in both plant and animal cell, however centriole and aster is only made in animal cell. T or F?
True
________ cell is known as amphiastral whereas ______ cell is known as anastral.
Animal, plant
__________ is the most dramatic period of the cell cycle involve reorganisation of virtually all components
M Phase
Why is M Phase division also called equational division?
Since the number of chromosomes is same in parents and progeny
Cell division is a progressive process with clear-cut lines between the various phases of M Phase. T or F?
False, clear cut lines cannot be drawn
Karyokinesis involves which 4 stages?
Prophase
Metaphase
Anaphase
Telophase
__________ is the first stage of karyokinesis of mitosis and follows the ______ phases of interphase
Prophase, S and G2
How do the new DNA molecules in S and G2 phases look?
Intertwined, not distinct
Prophase is marked by __________
initiation of condensation of chromosomal material
The centrosome undergoes duplication during which phase?
S phase of interphase
During prophase, chromosomes become _______ (tangled/untangled), and are seen to be are composed of _____ (how many?) chromatids attached at _____
untangled, two, centromere
During prophase, __________ moves towards opposite poles of the cells. Each radiates out microtubules called ______.
centrosome/centrioles
asters
The __________ together with _____________ forms the mitotic/spindle apparatus
two asters of centrosome
spindle fibres
At the end of prophase, cells show nuclear envelope, nucleolus, golgi complexes and endoplasmic reticulum. T or F?
False, do not show
_____________ marks the start of the metaphase of mitosis.
Complete disintegration of the nuclear envelope
________ is aka spireme stage
Early prophase
Chromosomes are spread through the cytoplasm of the cell during which stage?
Metaphase
In mitosis, by ______ stage condensation of the chromosomes is completed.
Metaphase
In _____ phase chromosomes can be easily observed and their morphology is most easily studied.
Metaphase
Kinetochores are ______ shaped structures made of ______ at the surface of _________.
In metaphase, what purpose do they serve?
Small disc-shaped structures, proteins, centromeres
serve as sites of attachment of spindle fibres