Xanthines (lower resp tract) Flashcards
1
Q
Medications
A
caffiene
theophylline
- **narrow margin of safety!
- **interact with many drugs
- RESERVED FOR WHEN OTHER DRUGS DON’T WORK OR CRITICAL SITUATION IN ICU*
2
Q
Action
A
direct effect on smooth muscles of respiratory tract; affecting bronchi and blood vessels
exact MOA unknown
3
Q
Indications
A
symptomatic relief or prevention of bronchial asthma & reversal of COPD bronchospasm
4
Q
Contraindication
A
- lactation
5
Q
Cautions
A
- pregnancy
- GI problems
- CAD
- respiratory dysfunction
- renal or hepatic disease
- alcoholism
- hyperthyroidism
6
Q
Adverse Effects
A
Related to theophylline levels in blood:
- GI upset
- irritability
- tachycardia
- hyperglycemia
- seizures
- brain damage
- death
7
Q
Drug-Drug Interactions
A
- any drug metabolized in liver
- substances in cigarettes
