Sulfonylureas

Question 1

Medications

Answer 1

First gen:
-Chlorpropamide

Second gen:

• Glipizide
• Glyburide

Question 2

Action

Answer 2

• Stimulate insulin release from the beta cells in the pancreas
• Improve binding to insulin receptors

Question 3

First Gen

Answer 3

-Associated with increased risk of cardiovascular disease

Question 4

Second Gen

Answer 4

• Advantage over first gen
• Excreted in urine and bile
• Do not interact with many protein bound drugs
• Longer duration of action

Question 5

Indications

Answer 5

-Adjunct to diet and exercise to lower blood glucose levels in type 2 diabetes

Question 6

Contraindications

Answer 6

• Allergy
• Diabetic complications
• Type 1 diabetes
• Pregnancy/lactation

Question 7

Adverse effects

Answer 7

• Hypoglycemia
• GI distress
• Allergic skin reactions

Question 8

Drug-Drug interactions

Answer 8

• Drugs that acidify the urine
• Beta blockers
• Alcohol