Histamine-2 (H2) Antagonists

Question 1

Medication

Answer 1

“-tidine”

• cimetidine
• ranitidine
• famotidine

Question 2

Action

Answer 2

selectively blocks H2 receptors:

• lowers gastric acid secretion
• overall pepsin production

Question 3

Indications

Answer 3

• short term treatment of active duodenal ulcer or benign gastric ulcer
• Zollinger-Ellison syndrome (high secretions)
• stress-induced ulcers and acute upper GI bleeding in critical patients
• GERD
• heartburn
• acid indigestion
• sour stomach

Question 4

Contraindications/Cautions

Answer 4

• allergy

Cautions:

• pregnancy
• lactation
• hepatic dysfunction
• renal dysfunction

Question 5

Adverse Effects

Answer 5

• GI effects
• CNS effects
• cardiac arrhythmias
• hypotension

Question 6

Drug-Drug Interactions

Answer 6

MANY! Do not need to memorize, just know there are many!

warfarin, phenytoin, beta blockers, alcohol, quinidine, lidocaine, theophylline, chloroquine, benzodiazepines, nifedipine, pentoxifylline, tricyclics, procaidamide, carbamazepine