Proton Pump Inhibitors Flashcards
1
Q
Medications
A
“-prazole”
- omeprazole
- esomeprazole
- lansoprazole
- pantoprazole
- rabeprazole
2
Q
Action
A
Act at specific secretory surface receptors to prevent final step of acid production lowering stomach acid level
3
Q
Indications
A
Short-term treatment:
- active duodenal ulcers
- GERD
- erosive esophagitis
- benign active gastric disease
Long term:
- pathological hypersecretory conditions
4
Q
Contraindications
A
- allergy
- pregnancy
- lactation
5
Q
Adverse Effects
A
- dizziness - abdominal pain
- headache - tongue atrophy
- asthenia - cough
- vertigo - stuffy nose
- insomnia - hoarseness
- apathy - epistaxis
- diarrhea
6
Q
Drug-Drug Interactions
A
Clopidogrel = increased CV effects
Bensodiazepines, Phenytoin, Warfarin = increase risk of toxicity
Ketoconazole, theophylline = decreased levels
Sulcrafate = PPI’s not absorbed well