PCSK9 Inhibitors Flashcards
1
Q
Medications
A
“-ocumab”
- Alirocumab
- Evolocumab
2
Q
Action
A
-Monoclonal antibodies that bind to free PCSK9 enzyme inhibiting it from attaching to LDL receptors on the liver cell, allowing more LDL to be processed by the liver and less circulating
3
Q
Indications
A
-Treatment of high cholesterol levels with statin therapy or if statins are contraindicated
4
Q
Contraindications
A
-History of serious hypersensitivity reactions
5
Q
Adverse effects
A
- Risk of infection
- Injection site reactions
- Allergic reaction
6
Q
Drug-Drug interactions
A
-unknown
7
Q
Assessment
A
- History: Allergy, pregnancy/lactation
- Physical: VS, lung sounds
- Labs: cholesterol, lipids, liver fx
8
Q
Nursing diagnoses
A
- Acute pain
- Risk for infection
- Impaired skin integrity
- Deficient knowledge
9
Q
Implementation
A
- Monitor labs periodically
- Ensure pt has attempted lifestyle changes
- Provide comfort measures
- Provide pt teaching
10
Q
Evaluation
A
- Evaluate response to drug
- Evaluate effectiveness of the teaching plan
- Evaluate the effectiveness of comfort and safety measures/ compliance with regimen
