Thrombolytics (Clot Busters) Flashcards
1
Q
Medications
A
“-ase”
- Alteplase
- Reteplase
- Tenecteplase
- Urokinase
2
Q
Actions
A
-Activating plasminogen to plasmin, which in turn breaks down fibrin threads in a clot to dissolve a formed clot
3
Q
Indictions
A
- Acute MI
- Pulmonary emboli
- Ischemic stroke
4
Q
Contraindications
A
- Allergy
- Any condition that would be worsened by dissolution of clots
- Pregnancy
5
Q
Caution
A
-Lactation
6
Q
Adverse effects
A
- Bleeding
- Cardiac arrhythmias
- Hypotension
- Hypersensitivity: rash, flushing, bronchospasm, and anaphylactic shock
7
Q
Drug-Drug interaction
A
- Anticoagulants
- Antiplatelets
8
Q
Assessment
A
- History: check for contraindications
- Physical: skin, heart and lung sounds, CNS, perfusion, VS, ECG
- Labs: clotting studies, renal and hepatic fx, CBC, occult blood in stool
9
Q
Nursing diagnoses
A
- Risk for injury
- Ineffective tissue perfusion
- Decreased cardiac output
- Deficient knowledge
10
Q
Implementation
A
- Discontinue heparin if it is being given before admin of a thrombolytic agent
- Evaluate blood loss
- Monitor coagulation studies
- Institute within 6 hours after the onset of symptoms of acute MI
- Arrange to type and cross-match blood
- Safety precautions
- Provide pt teaching
11
Q
Evaluation
A
- Evaluate response to drug
- Evaluate effectiveness of teaching plan
- Evaluate effectiveness of comfort and safety measures
- Evaluate compliance with the regimen
