Thiazide and Thiazide-like Diuretics

Question 1

Medications

Answer 1

• Hydrochlorothiazide
• Chlorothiazide
• Chlorothalidone

Question 2

Action

Answer 2

• Blocks the chloride pump

- Keeps chloride and the sodium in the tubule to be excreted in the urine, thus preventing reabsorption

Question 3

Indications

Answer 3

• Treatment of edema associated with CHF, liver, or renal disease
• Monotherapy or adjunct for the treatment of hypertension

Question 4

Contraindications

Answer 4

• Allergy to thiazides or sulfonamides
• Fluid & electrolyte imbalances
• Renal disease
• Lactation

Question 5

Cautions

Answer 5

• SLE (lupus)
• Liver disease
• Pregnancy/lactation
• Diabetes or glucose tolerance abnormalities

Question 6

Adverse effects

Answer 6

• GI upset
• Fluid & electrolyte imbalances: hypokalemia, hypercalcemia
• Hypotension
• Hyperglycemia
• CNS effects: tingling, drowsiness, numbness, confusion
• Alkalinized urine

Question 7

Drug-Drug interactions

Answer 7

• Digoxin: increased risk of digoxin toxicity r/t potassium changes
• Antidiabetic agents: may need adjustment
• Lithium: risk of lithium toxicity, monitor levels closely