W1_09 Chronic Inflammation Flashcards

1
Q

three cardinal features of chronic inflammation?

A

non-neutophilic inflammation (macrophages, lymphocytes, plasma cells);
architectural destruction;
tissue fibrosis

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2
Q

macrophages secrete TNF and IL-1 to recruit which cell?

A

neutrophils

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3
Q

define granuloma

A

a collection of activated (epithelioid) macrophages surrounded by chronic inflammation and fibrosis (usually a rim of t cells)

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4
Q

define immune granuloma

A

poorly degradable antigen causes cell-mediated immune response (IL-2, INF-gamma)

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5
Q

define foreign body granuloma

A

inert material too big for a single macrophage to eat

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6
Q

how do b-cells participate in chronic inflammation?

A

they turn into activated plasma cells

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7
Q

remember that after treating the acute phase in an asthma attack, we need to treat for the late-phase as well

A

prevent the eosinophils and the lymphocytes from wreaking havoc

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8
Q

what are three types of immune-mediated chronic inflammation?

A

autoimmunity, immune dysregulation, hypersensitivity reactions

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