W1_09 Chronic Inflammation

Question 1

three cardinal features of chronic inflammation?

Answer 1

non-neutophilic inflammation (macrophages, lymphocytes, plasma cells);
architectural destruction;
tissue fibrosis

Question 2

macrophages secrete TNF and IL-1 to recruit which cell?

Answer 2

neutrophils

Question 3

define granuloma

Answer 3

a collection of activated (epithelioid) macrophages surrounded by chronic inflammation and fibrosis (usually a rim of t cells)

Question 4

define immune granuloma

Answer 4

poorly degradable antigen causes cell-mediated immune response (IL-2, INF-gamma)

Question 5

define foreign body granuloma

Answer 5

inert material too big for a single macrophage to eat

Question 6

how do b-cells participate in chronic inflammation?

Answer 6

they turn into activated plasma cells

Question 7

remember that after treating the acute phase in an asthma attack, we need to treat for the late-phase as well

Answer 7

prevent the eosinophils and the lymphocytes from wreaking havoc

Question 8

what are three types of immune-mediated chronic inflammation?

Answer 8

autoimmunity, immune dysregulation, hypersensitivity reactions