W1_09 Chronic Inflammation Flashcards
three cardinal features of chronic inflammation?
non-neutophilic inflammation (macrophages, lymphocytes, plasma cells);
architectural destruction;
tissue fibrosis
macrophages secrete TNF and IL-1 to recruit which cell?
neutrophils
define granuloma
a collection of activated (epithelioid) macrophages surrounded by chronic inflammation and fibrosis (usually a rim of t cells)
define immune granuloma
poorly degradable antigen causes cell-mediated immune response (IL-2, INF-gamma)
define foreign body granuloma
inert material too big for a single macrophage to eat
how do b-cells participate in chronic inflammation?
they turn into activated plasma cells
remember that after treating the acute phase in an asthma attack, we need to treat for the late-phase as well
prevent the eosinophils and the lymphocytes from wreaking havoc
what are three types of immune-mediated chronic inflammation?
autoimmunity, immune dysregulation, hypersensitivity reactions