W03_02 type 2,3,4 hypersensitivity

Question 1

what is type I hypersensitivity?

Answer 1

IgE-mediated

Question 2

what is type II hypersensitivity?

Answer 2

antibody-mediated. Complement is important here. Usually organ-specific

Question 3

what is type III hypersensitivity?

Answer 3

immune complex disease (precipitating complexes). Usually systemic, multiorgan)

Question 4

what is type IV hypersensitivity?

Answer 4

delayed-type hypersensitivity and other cell-mediated reactions

Question 5

what is goodpasture’s syndrome?

Answer 5

autoantibody to the glomerular basement membrane

Question 6

what is the equivalence zone?

Answer 6

largest precipitation (when neither antibody nor antigen is excess)

Question 7

on which side of the equivalence zone is immune complex disease more likely?

Answer 7

excess antigen

Question 8

what type of hypersensitivity is systemic lupus erythematosus?

Answer 8

type III (anti DNA antibodies)

Question 9

what type of hypersensitivity causes vasculitis?

Answer 9

type III

Question 10

what does TGF-beta do acutely? Chronically?

Answer 10

acutely: potent immunosuppressant (turn off T and B cells, but turn on Tregs), prevent cancer;
chronically: induce fibrosis. Can increase cancer

Question 11

note: polyclonal T-cell activation can result in lethal systemic inflammatory disease

Answer 11

e.g. bacterial superantigens that cause cytokine storm

Question 12

what is familial mediterranean fever (FMF)?

Answer 12

mutation of the pyrin gene that causes excessive IL-1 production. Example of inherited autoinflammatory syndrome