W1_07 Aging and Cellular Senescence Flashcards
1
Q
what’s werner’s syndrome?
A
mutation of DNA helicase that causes people to age more quickly
2
Q
recall telomeres?
A
good.
3
Q
which end is the telomere on?
A
3’. (thus the 5’ end of new strand is shortened)
4
Q
how do telomeres get longer?
A
telomerase enzyme
5
Q
give an example of a gene mutation that lead to slower aging and lifespan extension
A
IGF (levels decreased)
6
Q
what is the molecular mediator believed to be a player in caloric restriction lifespan extension?
A
sirtuins, which induce genes that resist cell stress, and increase insulin sensitivity+glucose metabolism
7
Q
what is resveratrol?
A
plant polyphenol; believed to activate sirtuin, but not clear
8
Q
note, while telomerases contribute to replicative senescence, it’s unclear how RS ties in with aging
A
ok
